Abstract: FR-PO1115
Sex Differences in Handgrip Strength in Nondialysis-Dependent CKD
Session Information
- CKD: Epidemiology, Risk Factors, and Prevention - 2
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Li, Amy Shijia, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States
- Dixon, Angelina Magreni, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States
- You, Zhiying, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States
- Kendrick, Jessica B., University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States
Background
Handgrip strength (HGS) is a simple, reliable measure of skeletal muscle function and a surrogate marker of protein-energy status and functional status in patients with chronic kidney disease (CKD). We assessed HGS using the NIH Toolbox grip strength test in CKD patients.
Methods
We studied 105 individuals (49.5% women) with CKD stage 3b-4 (eGFR 15-44 ml/min/1.73m2). HGS was measured using the NIH Toolbox grip strength test, a standardized and validated test in the US population, with the Jamar Plus Digital dynamometer.
Results
The mean (SD) age and eGFR were 61 ± 12 years and 34.9 ± 9.8 mL/min/1.73m2. When compared to the NIH Toolbox reference population, CKD participants scored, on average, below the 50th percentile on HGS in both the dominant and nondominant hand. Women scored in a significantly lower percentile than men, p<0.0001. When adjusted for age, sex, race/ethnicity, and education level, women had a higher dominant mean grip strength score than men but this was not statistically significant. There were no significant differences in HGS between participants with CKD stage 3b or 4.
Conclusion
Participants with CKD have lower HGS when compared to the general population, with women scoring in a significantly lower percentile than men. Women tended to have greater dominant grip strength compared to men, but this was not statistically significant. Further studies are needed to study sex differences in skeletal muscle function in CKD.
| Men Adjusted Score | Men Percentile | Women Adjusted Score | Women Percentile | p-value Adjusted Score | p-value Percentile | |
| Grip Strength (pounds) | ||||||
| Dominant hand | 43.3 ± 13.9 | 64.2 ± 26.4 | 47.5 ± 9.5 | 28.2 ± 18.1 | 0.08 | <0.001 |
| Nondominant hand | 43.9 ± 11.8 | 65.4 ± 24.6 | 46.1 ± 8.4 | 25.2 ± 17.5 | 0.29 | <0.001 |
| CKD stage 3b Adjusted Score | CKD stage 3b Percentile | CKD stage 4 Adjusted Score | CKD stage 4 Percentile | p-value Adjusted Score | p-value Percentile | |
| Grip Strength (pounds) | ||||||
| Dominant hand | 46.5 ± 11.3 | 49.4 ± 29.5 | 43.0 ± 13.5 | 42.1 ± 29.4 | 0.16 | 0.23 |
| Nondominant hand | 45.5 ± 10.4 | 47.7 ± 28.8 | 43.9 ± 10.3 | 42.9 ± 30.6 | 0.45 | 0.44 |
Mean (SD) Adjusted score: adjusted for age, sex, race/ethnicity and education level
Funding
- Other NIH Support