Kidney Week

Abstract: FR-PO1145

Quantification of Muscle Wasting in CKD by Texture Analysis on 1H-Magnetic Resonance Images

Session Information

• CKD: Kidney Function and Extrarenal Complications
  October 25, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2302 CKD (Non-Dialysis): Clinical, Outcomes, and Trials

Authors

• Hur, Lisa, Western University, London, Ontario, Canada

Lisa Hur, PhD

• Latman, Nicole, London Health Sciences Centre, London, Ontario, Canada

Nicole Latman

• Akbari, Alireza, London Health Sciences Centre, London, Ontario, Canada

Alireza Akbari, PhD

• Dorie, Justin R., London Health Sciences Centre, London, Ontario, Canada

Justin R. Dorie, LPN/VN

• Tamasi, Tanya, London Health Sciences Centre, London, Ontario, Canada

Tanya Tamasi, RN

• McIntyre, Christopher W., London Health Sciences Centre, London, Ontario, Canada

Christopher W. McIntyre, MD, MBBS

Background

Functionally significant muscle wasting is prevalent in chronic kidney disease (CKD). Currently, muscle quality assessment requires biopsy and microscopy. ¹H-Magnetic Resonance Imaging (MRI) is non-invasive and can be used to assess changes in skeletal muscle composition. This study aims to utilize ¹H-MRI to establish a quantitative metric for muscle heterogeneity, a potential biomarker of muscle quality and composition in patients with CKD, both requiring hemodialysis (HD) and earlier stages.

Methods

¹H T1-weighted axial images (3 Tesla) of the calf were acquired on 43 CKD, 34 HD, and 8 with cardiorenal syndrome (CR). Gastrocnemius and soleus muscles were delineated and the heterogeneity quantification algorithm was applied. The magnitude of pixel intensity gradation between pixel-pair combinations was computed, resulting in a value, zeta, to represent the mean heterogeneity. A one-way ANOVA was performed for significance in heterogeneity between the three cohorts. Combining all participants (n=85), Pearson correlations was completed for blood markers of kidney function in relation to muscle heterogeneity.

Results

Muscle heterogeneity of HD and CR were comparable but significantly more heterogeneous relative to CKD (Figure 1). Negative correlations were seen with albumin and 1,25 Vitamin D with relation to muscle heterogeneity (Figure 2A, B). A positive association was seen with PTH with respect to muscle heterogeneity (Figure 2C).

Conclusion

Muscle heterogeneity of HD and CR may be indicative of fibrosis and wasting that is more pronounced than progressive CKD not on dialysis. Relationship between blood markers of kidney function and muscle heterogeneity suggest texture analysis to be a useful tool for non-invasive evaluation of kidney disease on skeletal muscle structure and function.

Funding

• Government Support – Non-U.S.