Kidney Week

Abstract: SA-PO1106

Effect of Ambient Temperature on Renal Colic: A Systematic Review and Meta-Analysis

Session Information

• CKD: Epidemiology, Risk Factors, and Prevention - 3
  October 26, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Kovesdy, Csaba P., University of Tennessee Health Science Centre, Memphis, Tennessee, United States

Csaba P. Kovesdy, MD, FASN

• Mazumder, Hoimonty, The University of Memphis, Memphis, Tennessee, United States

Hoimonty Mazumder, MBBS, MPH

• Faizah, Farah, The University of Memphis, Memphis, Tennessee, United States

Farah Faizah, MD, MPH

• Alam, Naznin, The University of Memphis, Memphis, Tennessee, United States

Naznin Alam, MSc

• Mou, Xichen, The University of Memphis, Memphis, Tennessee, United States

Xichen Mou

• Zhang, Hongmei, The University of Memphis, Memphis, Tennessee, United States

Hongmei Zhang, PhD

• Naser, Abu Mohd, The University of Memphis, Memphis, Tennessee, United States

Abu Mohd Naser, MBBS, PhD

Background

Renal colic is a clinical manifestation characterized by spasmodic pain in the lower back, which is commonly caused by kidney stones. Although limited, recent evidence suggests increased risk of kidney outcomes in exposure to elevated ambient temperature. In this meta-analysis, we aimed to elucidate the effect of ambient temperature on renal colic.

Methods

We systematically searched four leading bibliographic databases (PubMed, CINAHL complete, Scopus, and Web of Sciences) and additional sources from the inception of each database to February 12, 2024. Epidemiological studies that met a pre-determined eligibility criteria following PECOS (population, exposure, comparator, outcome, and study design) were included. The effect sizes from individual studies were standardized to Cohen’s d and we performed a meta-analysis with a random-effects model to estimate a pooled Cohen’s d and constructed a 95% confidence interval. We performed further sub-group analyses by study region, sample size, study design, and mean age of study participants.

Results

Out of 1463 primarily retrieved articles, seven articles representing 758666 study participants underwent meta-analysis. Most of the studies were conducted in the US (3) followed by China (2), Canada (1), and Israel (1). Ambient temperature demonstrated a significant effect on renal colic [Cohen’s d: 0.30, 95% CI: 0.18, 0.41, p-value < 0.001, I² = 99.08%]. Subgroup analyses for potential explanation of heterogeneity demonstrated statistically significant between-group variance for study region [America- Cohen’s d: 0.25, (95% CI: 0.11, 0.39); Asia - Cohen’s d: 0.44, (95% CI: 0.42, 0.45)] and study design [Case-crossover- Cohen’s d: 0.46, (95% CI: 0.01, 0.93); Retrospective cohort - Cohen’s d: 0.44, (95% CI: 0.42, 0.45); Time-series - Cohen’s d: 0.21, (95% CI: 0.17, 0.25)].

Conclusion

These findings suggest a moderate effect of ambient temperature on renal colic.

Figure 1: Forest plot showing summary-effect.