Kidney Week

Abstract: SA-PO208

Burden of Kidney Cancer Attributable to Smoking in 38 Organisation for Economic Cooperation and Development (OECD) Countries, 1990-2021: Insights from the Global Burden of Disease Study 2021

Session Information

• Onconephrology: Kidney Outcomes during Cancer Treatment and Nephropathies
  October 26, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Onconephrology

• 1700 Onconephrology

Authors

• Pudhota, Harsha Choudary, Guntur Medical College, Guntur, Andhra Pradesh, India

Harsha Choudary Pudhota, MBBS

• Purohit, Sree Abhilekha, Shadan Institute of Medical Sciences College of Nursing, Hyderabad, Telangana, India

Sree Abhilekha Purohit, MBBS

• Bhavanam, Sravani, Sri Devaraj Urs Medical College, Karnataka, India

Sravani Bhavanam, MBBS

• Shandilya, Ashwinikumar, Rural Medical College, Pravara Institute of Medical Sciences, Ahmednagar, India

Ashwinikumar Shandilya, MBBS

• Syed, Saif, Royal College of Surgeons in Ireland, Dublin, Ireland

Saif Syed, MD

• Lakkimsetti, Mohit, Mamata Medical College, Khammam, Telangana, India

Mohit Lakkimsetti, MBBS

• Patel, Juhi, Gujarat Medical Education and Research Society Medical College & Hospital Valsad, Valsad, Gujarat, India

Juhi Patel, MBBS

• Desai, Hardik, Gujarat Adani Institute of Medical Science, Bhuj, Gujarat, India

Hardik Desai, MBBS

• Amin, Vishrant, Gujarat Medical Education and Research Society Medical College & Hospital Valsad, Valsad, Gujarat, India

Vishrant Amin, MBBS

Background

Kidney cancer (KC) is on the rise globally, presenting significant concerns. Among modifiable risk factors, this study focuses on the impact of smoking on KC across 38 Organization for Economic Cooperation and Development (OECD) countries over the past three decades. This study is pioneering in its assessment of the burden during the initial two years of the COVID-19 pandemic, a period that significantly challenged cancer management.

Methods

Utilizing the Global Burden of Disease (GBD) 2021 tool, we estimated the deaths, disability-adjusted life years (DALYs), and years lived with disability (YLDs) attributed to KC attributable to smoking by age, sex, year, and location across these countries from 1990-2021.

Results

The total percentage change (TPC) in death counts increased by 26% (95% UI: 10-41%), DALYs by 9% (2-20%), and YLDs by 56% (39-71%) from 1990-2021. The highest number of age-standardized mortality rates (ASMR) was observed in Czechia at 0.69 cases, followed by Poland at 0.55, and while the US at 0.36 cases per 100,000 in 2021. Individuals aged 70-74 years recorded the highest number of deaths at 1,423 (821-2,122), while those aged 65-69 years showed the highest DALYs at 30,932 (18,383-45,164). In terms of gender differences over the last three decades, males experienced a higher burden compared to females, with TPC in deaths at 29% versus 15%, DALYs increased by 11% for males while decreasing by 1% for females, and YLDs at 61% versus 39%.

Conclusion

KC attributable to smoking accounted for 10.24% of all KC-related deaths in 2021. From the perspective of public stakeholders and policymakers, it is crucial to encourage smoking cessation and implement e-health or m-health education initiatives to reduce this burden.