Kidney Week

Abstract: TH-PO958

Sarcopenia in Patients on Hemodialysis in Brazil: Results of the SARC-HD Study

Session Information

• Physical Activity and Lifestyle in Kidney Diseases
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Health Maintenance, Nutrition, and Metabolism

• 1500 Health Maintenance, Nutrition, and Metabolism

Authors

• Ribeiro, Heitor S., Universidade de Brasilia Faculdade de Ciencias da Saude, Brasilia, Federal District, Brazil

Heitor S. Ribeiro, PhD

• Duarte, Marvery P., Universidade de Brasilia Faculdade de Ciencias da Saude, Brasilia, Federal District, Brazil

Marvery P. Duarte, MSc

• Nobrega, Otavio, Universidade de Brasilia Faculdade de Ciencias da Saude, Brasilia, Federal District, Brazil

Otavio Nobrega, PhD

• Vieira, Fábio Augusto Silva, Universidade de Brasilia Faculdade de Ciencias da Saude, Brasilia, Federal District, Brazil

Fábio Augusto Silva Vieira

• Silva, Maryanne, Universidade Estadual Paulista Julio de Mesquita Filho, Botucatu, Brazil

Maryanne Silva, PhD, RDN

• Mondini, Dário R., Universidade Estadual de Campinas, Campinas, SP, Brazil

Dário R. Mondini

• Maggi Sant'Helena, Bruna, Faculdade IELUSC, Joinville, SC, Brazil

Bruna Maggi Sant'Helena, PhD

• Disessa, Henrique Santos, Universidade Estadual Paulista Julio de Mesquita Filho, Bauru, Brazil

Henrique Santos Disessa, MSc

• Adamoli, Angélica Nickel, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil

Angélica Nickel Adamoli, PhD

• Bundchen, Daiana C., Universidade Federal de Santa Catarina, Ararangua, Brazil

Daiana C. Bundchen, PhD

• Krug, Rodrigo de Rosso, Universidade de Cruz Alta, Cruz Alta, Brazil

Rodrigo de Rosso Krug

• Inda-Filho, Antonio Jose, Centro Universitario ICESP, Brasilia, DF, Brazil

Antonio Jose Inda-Filho, MD, PhD

• Avesani, Carla Maria, Karolinska Institutet, Stockholm, Stockholm, Sweden

Carla Maria Avesani, PhD, RD

• Vogt, Barbara Perez, Universidade Federal de Uberlandia, Uberlandia, Brazil

Barbara Perez Vogt, PhD, RD

• Reboredo, Maycon Moura, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil

Maycon Moura Reboredo, PhD

Group or Team Name

• SARC-HD Study Group.

Background

Sarcopenia is a common feature of patients on hemodialysis and is strongly associated with adverse clinical outcomes, but its epidemiology in middle-income countries remains underexplored. We described the prevalence and risk factors for sarcopenia in patients on hemodialysis in Brazil.

Methods

Baseline data from the SARC-HD multicenter study was analyzed. Muscle strength was assessed by handgrip; muscle mass by calf circumference; and physical performance by gait speed. Sarcopenia diagnosis and staging were based on the revised EWGSOP2 as probable, confirmed, and severe sarcopenia. Prevalence rates were compared among clinical and sociodemographic characteristics and risk factors analyzed.

Results

983 patients (median 59 years; 40% female) from 19 Brazilian dialysis centers were enrolled. Prevalences of probable, confirmed, and severe sarcopenia were 12%, 9%, and 5%, respectively. The prevalence of sarcopenia increased with advancing age groups, ranging from 7% to 45% in males and from 4% to 21% in females. After adjustment for confounders, male sex (odds ratio [OR]:1.7, 95% confidence interval [CI]:1.1–2.7), older age (OR:3.4, 95%CI:2.2–5.4), white ethnicity (OR:1.8, 95%CI:1.2–2.8), hemodiafiltration treatment (OR:1.6, 95%CI:1.1–2.4), and catheter access (OR:1.6, 95%CI:1.0–2.4) were the main risk factor for sarcopenia; however, overweight (body mass index ≥25.0 kg/m²) was a protective factor (OR:0.3, 95%CI:0.2–0.4).

Conclusion

Any stage of sarcopenia was found in one out of four patients on hemodialysis. Male sex, older age, white ethnicity, hemodiafiltration treatment, and catheter access were risk factors for presenting sarcopenia. Our findings enhance the understanding of sarcopenia in patients on hemodialysis in Brazil.

Figure 1. Prevalence of sarcopenia stratified by age groups and sex.

Funding

• Government Support – Non-U.S.