Abstract: TH-PO273
Correlation between Intradialytic Blood Pressure Variability and Cognitive Impairment in Patients on Maintenance Hemodialysis
Session Information
- Hemodialysis and Frequent Dialysis - 1
October 24, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Wan, Jingfang, Army Medical Center of PLA, Chongqing, Chongqing, China
- Liu, Jun, Army Medical Center of PLA, Chongqing, Chongqing, China
- He, Yani, Army Medical Center of PLA, Chongqing, Chongqing, China
- Chen, Kehong, Army Medical Center of PLA, Chongqing, Chongqing, China
Background
Cognitive impairment (CI) is a risk factor for death and poor prognosis in maintenance hemodialysis (MHD) patients. MHD patients are more likely to have fluctuating BP during dialysis, which may have a greater impact on CI. Our present study aimed to illustrate the correlation between intradialysis BPV and CI in MHD patients.
Methods
Overall cognitive function was assessed by the Beijing version of the Montreal Cognitive Assessment (MoCA-B) scale. The patient's SBP was converted to the following 4 candidate BPV indices: standard deviation (SD), coefficient of variation (CV), average real variability (ARV), RANGE. P < 0.05 was considered statistically significant.
Results
170 patients were enrolled, with a total of 6,662 dialysis recordings and 26,580 SBP measurement recordings. The mean age of the patients was 57.99 years. The proportion of males was 58.24%, and CI prevalence was 78.24%. SBP ARV is an independent risk factor for CI (Table 1). We observed a non-linear relationship between SBP ARV and CI (Figure 1). We compared two fitting models to explore the curved associations, the p-value of the log-likelihood ratio test is 0.008. The inflection point of SBP ARV was 7.52. When SBP ARV ≥ 7.52, the risk of CI increased as the SBP ARV increased (OR: 4.10, 95 % CI1.61-10.46, P = 0.003). When SBP ARV < 7.52, there was no significant correlation between SBP ARV and CI (OR = 0.43, 95 % CI 0.15-1.26, p = 0.125).
Conclusion
Intradialytic BPV was associated with CI in MHD patients. Intradialytic SBP ARV may be a better candidate for predicting CI in MHD patients, with nonlinear dose-response relationship.
Table1. The results of mutivariate analysis between SBP ARV and CI
Figure 1. Curve fitting between SBP ARV and CI.
Funding
- Government Support – Non-U.S.