Kidney Week

Abstract: TH-PO918

Clinical Implementation Framework of Anemia Control Model in Singapore

Session Information

• Anemia and Iron Metabolism
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Anemia and Iron Metabolism

• 200 Anemia and Iron Metabolism

Authors

• Ion Titapiccolo, Jasmine, Fresenius Medical Care AG, Bad Homburg, Hessen, Germany

Jasmine Ion Titapiccolo, PhD

• Nikam, Milind, Fresenius Medical Care AG, Singapore, Singapore

Milind Nikam, MD, MBBS

• Mooppil, Nandakumar, Fresenius Medical Care AG, Singapore, Singapore

Nandakumar Mooppil, MD, MBBS

• Singh, Tripti, Fresenius Medical Care AG, Singapore, Singapore

Tripti Singh, MD, DrMed

• Gualdoni, Andrea, Fresenius Medical Care AG, Hong Kong, China

Andrea Gualdoni, MSc

• Hymes, Jeffrey L., Fresenius Medical Care AG, Boston, Massachusetts, United States

Jeffrey L. Hymes, MD

• Larkin, John W., Fresenius Medical Care AG, Boston, Massachusetts, United States

John W. Larkin, PhD

• Usvyat, Len A., Fresenius Medical Care AG, Boston, Massachusetts, United States

Len A. Usvyat, PhD

• Bellocchio, Francesco, Fresenius Medical Care AG, Bad Homburg, Hessen, Germany

Francesco Bellocchio

• Neri, Luca, Fresenius Medical Care AG, Bad Homburg, Hessen, Germany

Luca Neri, MD, PhD

• Yeung, Julianna, Fresenius Medical Care AG, Hong Kong, China

Julianna Yeung, MSc, MPH

Background

The efficacy and safety of the Anemia Control Model (ACM) in Europe is well documented. Since 2021, ACM was piloted and implemented in Singapore. We sought to report the uptake and outcomes of ACM in the first two years of clinical implementation.

Methods

Our clinical implementation framework was based on incremental piloting and expanding the use of ACM progressively in additional clinics (Fig 1). We evaluated hemoglobin (Hb) target achievement over 12-months follow up.

Results

In a preclinical feasibility analysis ACM accurately predicted Hb levels (mean absolute error=0.66). We piloted ACM in three clinics for usability and clinical performance and gradually expanded in the full network over two years. Doctors assessed 6597 suggestions generated by ACM (52% were accepted). ACM target achievement was higher in patients treated according to ACM suggestion (p<0.05) (Fig 2).

Conclusion

Despite improved target achievement, the uptake of ACM suggestions in clinical practice is still partial. More research should be conducted in advancing clinical implementation framework of artificial intelligence so that this technology can be more effectively utilized in clinical practice.

Figure1. ACM clinical implementation framework.

Figure 2: Percentages of patient achieving Hb target.

Funding

• Commercial Support – Fresenius Medical Care