Kidney Week

Abstract: TH-PO1016

Association between Environmental Factors and Kidney Diseases: A Nationwide Population-Based Study

Session Information

• CKD: Epidemiology, Risk Factors, and Prevention - 1
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Cho, Semin, Chung-Ang University Gwangmyeong Hospital, Gyeonggi-do, Korea (the Republic of)

Semin Cho, MD

• Cho, Jeongmin, Chung-Ang University Gwangmyeong Hospital, Gyeonggi-do, Korea (the Republic of)

Jeongmin Cho, MD

• Lee, Soojin, Eulji University Uijeongbu Eulji Medical Center, Uijeongbu, Gyeonggi-do, Korea (the Republic of)

Soojin Lee, MD, PhD

• Park, Sehoon, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)

Sehoon Park, MD, PhD

• Han, Kyungdo, Soongsil University, Dongjak-gu, Seoul, Korea (the Republic of)

Kyungdo Han, PhD

• Kim, Dong Ki, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)

Dong Ki Kim, MD, PhD

• Kim, Yaerim, Keimyung University Daegu Dongsan Hospital, Daegu, Korea (the Republic of)

Yaerim Kim, MD, PhD

Background

It is well known that various environmental factors including air pollution increase the risk of kidney disease. We aimed to elucidate the risk of chronic kidney disease according to the indoor air quality and urinary volatile organic compounds (VOCs) using data from the Korea National Health and Nutrition Examination Survey (KNHANES).

Methods

The ratio of indoor and ambient PM2.5 and urine creatinine-corrected VOCs concentration were extracted from the KNHANES VIII (2019-2021) dataset. CKD was defined as estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73m², and the association between environmental factors and CKD was analyzed through multiple linear regression model.

Results

A total of 1,319 participants was analyzed in this study. The highest quartile of indoor and ambient PM2.5 ratio was associated with increased risk of CKD (odds ratio(OR), 4.28; 95% confidence interval(95% CI), 1.43-12.75) after adjustment of age, sex, comorbidities, and window opening status. The urinary concentration of several VOCs (3,4MHA [3,4-Methylhexanoic Acid], PGA [Phenylglyoxylic Acid], MA [Maleic Acid], DHBMA [Dihydroxybenzene Mercapturic Acid]) have been found to have statistically significant association with reduced kidney function. ([3,4MHA] OR, 5.86; 95% CI, 1.30-26.45; [PGA] OR, 14.30; 95% CI, 1.53-133.78; [MA] OR, 5.38; 95% CI, 1.03-28.12; [DHBMA] OR, 4.14; 95% CI, 0.77-22.21).

Conclusion

In this cross-sectional study, the indoor air quality of PM2.5 relative to the concentration of PM2.5 in the ambient air was associated with the deterioration of kidney function and urinary VOCs concentration showed the association with declined kidney function which could be used to be a predictive marker of CKD.