Kidney Week

Abstract: SA-OR90

Triglyceride-Glucose Index and Risk of Cardiovascular Events, Kidney Allograft Loss, and New-Onset Diabetes after Transplantation in Kidney Transplant Recipients

Session Information

• Transplantation: Clinical Management and Monitoring
  October 26, 2024 | Location: Room 25, Convention Center
  Abstract Time: 05:50 PM - 06:00 PM

Category: Transplantation

• 2102 Transplantation: Clinical

Authors

• Lee, Yu ho, CHA University Bundang Medical Center, Seongnam, Gyeonggi-do, Korea (the Republic of)

Yu ho Lee, MD, PhD

• Kim, Jin Sug, Kyung Hee University Medical Center, Dongdaemun-gu, Seoul, Korea (the Republic of)

Jin Sug Kim, MD, PhD

• Jeong, Kyunghwan, Kyung Hee University Medical Center, Dongdaemun-gu, Seoul, Korea (the Republic of)

Kyunghwan Jeong, MD, PhD

• Yoon, Soo-Young, Kyung Hee University Medical Center, Dongdaemun-gu, Seoul, Korea (the Republic of)

Soo-Young Yoon, MD, PhD

• Jeong, Hyeyun, CHA University Bundang Medical Center, Seongnam, Gyeonggi-do, Korea (the Republic of)

Hyeyun Jeong, MD

• Baek, Jihyun, CHA University Bundang Medical Center, Seongnam, Gyeonggi-do, Korea (the Republic of)

Jihyun Baek, MD, DrMed

• Lee, So-young, CHA University Bundang Medical Center, Seongnam, Gyeonggi-do, Korea (the Republic of)

So-young Lee, MD, DrMed, PhD

• Hwang, Hyeon Seok, Kyung Hee University Medical Center, Dongdaemun-gu, Seoul, Korea (the Republic of)

Hyeon Seok Hwang, MD, PhD

Background

Insulin resistance is prevalent disorder, but its clinical significance remains undermined. We explored the clinical implication of triglyceride-glucose (TyG) index in renal transplant recipients, recognizing it as a valuable marker for insulin resistance.

Methods

A total of 6,354 renal transplant recipients were enrolled from a nationwide, prospective cohort between May 2014 and December 2022. The TyG index was assessed between 6- and 12-months post-transplantation. We evaluated the association between TyG index and the risk of composite of cardiovascular events and death, renal allograft loss, and new onset diabetes after transplantation (NODAT).

Results

During the mean follow-up period of 39.2 ± 26.1 months, a total of 106 composite events of cardiovascular events and death, 174 events of renal allograft loss, and 438 events of NODAT were observed. The cumulative rate for composite events, graft loss, and NODAT was greater in patients with higher TyG quartile (all P < 0.001). In multivariate analysis, patients in quartile 4 TyG index was associated with an increased risk of composite events (HR 1.81, 95% CI 1.14 – 2.86), renal allograft loss (HR 2.13, 95% CI 1.28 – 3.55), and NODAT (HR 2.52, 95% CI 1.90 – 3.34). Higher quartile of TyG was associated with future graft dysfunction (adjusted mean eGFR differences of -4.72, 95% CI -7.39 – -2.04). There was a linear escalation in the risk of composite events and graft loss with the incremental rise in the TyG index, concomitant with an exponential augmentation in the risk of NODAT.

Conclusion

Renal transplant recipients with higher TyG index are associated with higher risk of composite of cardiovascular event and death, renal allograft loss, and NODAT.