Kidney Week

Abstract: TH-PO284

Relationship between Muscle Mass, Strength, and Physical Performance in Patients on Maintenance Hemodialysis

Session Information

• Hemodialysis and Frequent Dialysis - 1
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Dialysis

• 801 Dialysis: Hemodialysis and Frequent Dialysis

Authors

• Park, Daeun, Yeungnam University School of Medicine and College of Medicine, Daegu, Korea (the Republic of)

Daeun Park

• Kang, Seok hui, Yeungnam University School of Medicine and College of Medicine, Daegu, Korea (the Republic of)

Seok hui Kang, PhD

Background

A relationship between muscle mass, muscle strengh, and physical performance in hemodialysis (HD) patients could be not established by a unidirectional pathway. This study aimed to assess the causal association of the aforementioned three variables using a mediation analysis.

Methods

We included 84 HD patients. The collected data included appendicular lean mass index (ALM/Ht²), handgrip strength (HGS), gait speed (GS), five-times sit-to-stand test, 30-s-sit-to-stand test (STS30), 6-min walk test (6MWT), timed up and go test, and short physical performance battery. Mediation analysis was done using Baron and Kenny’s regression approach to investigate the mediating effect.

Results

The mean ALM/Ht² and HGS were 6.6 ± 1.0 kg/m² and 26.1 ± 7.4 kg, respectively. ALM/Ht² or HGS showed a positive association with GS, STS30, or 6MWT, and the association between ALM/Ht² and HGS was significant. After adjusting for HGS, the association between ALM/Ht² and three physical performances did not remain significant; however, after adjusting for ALM/Ht², the association between HGS and three physical performances remained significant.

Conclusion

The present study demonstrated that physical performance tests were associated with both ALM/Ht² and HGS, but the association between ALM/Ht² and physical performance tests is completely mediated by HGS.