Abstract: FR-PO1050
Beverage Patterns and Risk of CKD Progression in the Diet, CKD, and Apolipoprotein L1 (DCA) Study
Session Information
- Kidney Nutrition and Metabolism
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Adebile, Tolulope V., Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States
- Zhao, Runqi, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States
- Umeizudike, Theophilus I., Lagos State University College of Medicine, Ojo, Lagos State, Nigeria
- Omotoso, Bolanle Aderonke, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Osun State, Nigeria
- Ripiye, Nanna R., University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria
- Raji, Yemi R., University of Ibadan and University College Hospital, Ibadan, Oyo, Nigeria
- Eduful, Ernestina, The Bank Hospital, Accra, Ghana
- Gbadegesin, Rasheed A., Duke University Medical Center, Durham, North Carolina, United States
- Kwakyi, Edward Papa Kwabena, Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana
- Mamven, Manmak, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria
- Solarin, Adaobi, Lagos State University College of Medicine, Ojo, Lagos State, Nigeria
- Ulasi, Ifeoma I., College of Medicine, University of Nigeria, Nsukka, Nigeria
- Adu, Dwomoa, Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana
- Ojo, Akinlolu, The University of Kansas School of Medicine, Kansas City, Kansas, United States
- Waikar, Sushrut S., Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States
- Parekh, Rulan S., Department of Medicine, Women’s College Hospital, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
- Mitchell, Diane C., Texas A&M AgriLife Research, College Station, Texas, United States
- Ilori, Titilayo O., Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States
Background
A few studies have established a relationship between beverage patterns and CKD progression, with sugar-sweetened beverages increasing the risk of CKD. We aim to identify beverage consumption patterns of well-phenotyped West Africans with CKD and examine their association with CKD progression.
Methods
We conducted a prospective analysis from the DCA cohort (n=748) to investigate diet-gene interactions in APOL1. We included data from a subset of participants with complete information on beverage intake from the 24-hour dietary recalls. CKD progression was defined as ≥40% decline from baseline eGFR at enrollment to DCA (2021-2023) and initiation of dialysis. Beverage consumption patterns were identified through principal component (PC) analysis, and their associations with CKD progression were analyzed using multivariate Cox proportional hazard models.
Results
There were 52 cases of CKD progression over a median follow-up period of 31 (IQR: 33.41,25.17) months. We identified four beverage patterns (Table), of which Low Sugar-Sweetened Beverages Plus Alcohol Beverage Pattern demonstrated a significantly lower risk of CKD progression [tertile 2 vs 1 HR: 0.42, 95% CI: 0.19,0.93].
Conclusion
The Low Sugar-Sweetened Beverages Plus Alcohol Beverage Pattern was associated with lower risk of CKD progression, indicating that moderate adherence to this pattern is linked to a reduced risk of CKD progression. The study is the first to establish the beverage patterns of well-phenotyped West African CKD patients and their association with CKD progression. Future investigations should conduct long-term prospective studies to validate and further explore the observed association.
Funding
- NIDDK Support – Department of Medicine, Boston Medical Center.