Kidney Week

Abstract: FR-PO962

Temporal and Demographic Trends in Medical Kidney Disease Epidemiology in the Southwestern United States, 1993-2022

Session Information

• Pathology and Lab Medicine - 1
  October 25, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Pathology and Lab Medicine

• 1800 Pathology and Lab Medicine

Authors

• Takahashi, Akira, Cedars-Sinai Medical Center, Los Angeles, California, United States

Akira Takahashi, MD

• Kiyozawa, Daisuke, Cedars-Sinai Medical Center, Los Angeles, California, United States

Daisuke Kiyozawa, MD, PhD

• Miyauchi, Takamasa, Cedars-Sinai Medical Center, Los Angeles, California, United States

Takamasa Miyauchi, MD

• Ren, Yi Mi Kevin, Cedars-Sinai Medical Center, Los Angeles, California, United States

Yi Mi Kevin Ren, MD

• Doi, Toshiki, Hiroshima University Hospital, Hiroshima, Japan

Toshiki Doi, MD, PhD

• Choung, Hae Yoon Grace, Cedars-Sinai Medical Center, Los Angeles, California, United States

Hae Yoon Grace Choung, MD

• Lin, Mercury Y., Cedars-Sinai Medical Center, Los Angeles, California, United States

Mercury Y. Lin, MD

• Hou, Jean, Cedars-Sinai Medical Center, Los Angeles, California, United States

Jean Hou, MD

• Masaki, Takao, Hiroshima University Hospital, Hiroshima, Japan

Takao Masaki, MD, PhD

• Oda, Yoshinao, Kyushu University, Fukuoka, Japan

Yoshinao Oda

• Haas, Mark, Cedars-Sinai Medical Center, Los Angeles, California, United States

Mark Haas, MD, PhD

• Nast, Cynthia C., Cedars-Sinai Medical Center, Los Angeles, California, United States

Cynthia C. Nast, MD, FASN

• Yamashita, Michifumi, Cedars-Sinai Medical Center, Los Angeles, California, United States

Michifumi Yamashita, MD, PhD, FASN

Background

Epidemiological study identifies the prevalence of disease, and could provide the important information to shine new light on the pathogenesis and a basis for further hypothesis-driven research. In the United States, there is only a single large-scale epidemiological study for glomerular diseases from the Southeast. Here, we describe 30-year temporal and demographic trends in biopsy-proven, not only glomerular but also non-glomerular diseases in the Southwestern United States.

Methods

We selected native kidney biopsy cases classified into one of 35 widely recognized and common renal disease categories, referred to the Division of Renal Pathology at Cedars-Sinai Medical Center between 1993 and 2022. Biopsy era (1993-2002, 2003-2012, and 2013-2022) and demographics (age, sex, and race) were our primary and secondary predictors, respectively, and the relative frequency of each glomerular/non-glomerular disease subtype was our primary outcome.

Results

57,613 patients were identified, with a mean age 51.0 (±19.2) years, 52.2% men, 53.8% White, 19.5% Latino, 11.0% Black, 10.2% Asian, and 5.5% other race. Glomerular disease frequency was always higher than non-glomerular disease frequency. Among the glomerular diseases, the frequency of diabetic glomerulosclerosis was constantly and rapidly increasing (9.3%, 15.6%, and 23.8%, each 10 years), while those of other common glomerular disease subtypes were decreasing except for ANCA/pauci-immune glomerulonephritis. Among the non-glomerular diseases, acute tubular necrosis was increasing in the frequency. These temporal trends were largely preserved in all studied demographic subgroups (sex, race, age), although there were several cross-sectional differences of glomerular disease frequencies within each demographic subgroup.

Conclusion

We provided the largest and latest epidemiological data about native kidney biopsy, which may provide valuable insights for nephrologists and pathologists to characterize various kidney diseases and its outcomes in the future, as well as to predict the relative likelihood of a disease diagnosis in a daily medical practice.