Abstract: PUB168
Temperature Regulation to Counter Inflammation Associated with Hemodialysis (TRIAD) Study
Session Information
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Author
- Bathini, Srikanth, Asian Institute of Nephrology and Urology, Hyderabad, Telangana, India
Background
CKD is a chronic inflammatory state. Inflammatory markers (IL-6, TNF- α) have been associated with adverse outcomes in CKD.The role of cool dialysate over standard temperature dialysate in preventing intra-dialytic hypotension is well known.The effect of a cool dialysate over inflammation is not known. We studied the effect of a cooled dialysate on inflammatory markers.
Methods
This is a prospective, randomised, open label study, with 13 patients in each group.Two groups with standard dialysate (36.50C) and cooler dialysate (one degree lesser than the core body temperature, never going below 350C) were studied.The inflammatory markers IL-6 and TNF-α were noted at baseline and at 8 months post randomization.
Results
The mean change in dialysate temperature from core body temperature was 0.90 0C in the cooled dialysate group. Cooled dialysate group had significantly lower intra-dialytic hypotension(p = 0.041).There was a statistically higher level of IL-6 (p < 0.05) at baseline in the control group. However, at 8 months, the difference was insignificant(p>0.05). There was no difference in TNF-α levels between both the groups at baseline and at 8 months post intervention(p>0.05).
Conclusion
The use of a cooled dialysate did not significantly lower inflammatory marker level in ESKD patients, but was was significantly associated with lower intradialytic hypotension. We recommend a larger trial to confirm the effect of cooled dialysate on the inflammatory milieu.
IL - 6 levels at baseline and after 8 months (pg/ml)
TNF-alpha levels at baseline and at 8 months (pg/ml)
Funding
- Private Foundation Support