Kidney Week

Abstract: TH-PO1040

Association of Pancreas Fat Fraction with Adverse Kidney and Cardiovascular Outcomes

Session Information

• CKD: Epidemiology, Risk Factors, and Prevention - 1
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Thomas, Philip Kenyon Woody, University of Illinois Chicago, Chicago, Illinois, United States

Philip Kenyon Woody Thomas, DO

• Missikpode, Celestin, University of Illinois Chicago, Chicago, Illinois, United States

Celestin Missikpode, PhD

• Verma, Ashish, Boston University, Boston, Massachusetts, United States

Ashish Verma, MBBS, FASN

• Zhao, Runqi, Boston University, Boston, Massachusetts, United States

Runqi Zhao, MS

• Claudel, Sophie E., Boston University, Boston, Massachusetts, United States

Sophie E. Claudel, MD

• Schmidt, Insa Marie, Boston University, Boston, Massachusetts, United States

Insa Marie Schmidt, MD, MPH

• Bjornstad, Petter, University of Washington, Seattle, Washington, United States

Petter Bjornstad, MD

• Layden, Brian, University of Illinois Chicago, Chicago, Illinois, United States

Brian Layden, MD, PhD

• Lash, James P., University of Illinois Chicago, Chicago, Illinois, United States

James P. Lash, MD, FASN

• Waikar, Sushrut S., Boston University, Boston, Massachusetts, United States

Sushrut S. Waikar, MD, MPH

• Srivastava, Anand, University of Illinois Chicago, Chicago, Illinois, United States

Anand Srivastava, MD, MPH

Background

Pancreas fat accumulation has been associated with impaired glucose metabolism and stimulation of inflammation. The associations of pancreatic fat fraction (PFF) with adverse outcomes remain understudied.

Methods

We estimated baseline predicted PFF (pPFF) from abdominal MRI in 29464 participants of the UK Biobank. Since the initial imaging visit occurred 9.3 [IQR 8.2,10.2] years after the baseline visit, we calculated annual change in PFF using linear regression in 337 participants who underwent repeat imaging 2.8 [IQR 2.2,4.8] years after the initial scan. We back-calculated pPFF by adding this change to each participant based on the time between the baseline visit and initial MRI visit assuming linear change in PFF over time. Multivariable-adjusted proportional hazards models tested associations of pPFF with incident chronic kidney disease (CKD), cardiovascular disease (CVD), and death.

Results

Participants had a mean ± SD age of 56 ± 8 years, mean eGFR of 98 ± 13 mL/min/1.73m², median [IQR] albuminuria of 5.7 [3.5,9.2] mg/g, and median pPFF of 4.7 [1.6,10.3]%. During a median follow-up of 13.8 years, there were 573 incident CKD events, 1049 incident CVD events, and 471 deaths. In fully adjusted models, participants in the 2^nd and 3^rd tertiles of pPFF each had a 1.58-fold increased risk of incident CKD compared to the 1^st tertile, respectively (Figure 1A). The association of pPFF with incident CKD was non-linear (Non-linear P<0.001, Figure 1B). pPFF was not associated with incident CVD or death.

Conclusion

Higher pPFF levels are associated with increased risk of incident CKD but not CVD or death. Future studies should investigate whether reducing pancreas fat decreases the risk of incident CKD.

Funding

• NIDDK Support