Kidney Week

Abstract: FR-PO1111

Impact of Bariatric Surgery on Kidney Function: A Prospective Analysis of Short-Term Outcomes

Session Information

• CKD: Epidemiology, Risk Factors, and Prevention - 2
  October 25, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Claure-Del Granado, Rolando, Universidad Mayor de San Simon, Cochabamba, Bolivia, Plurinational State of

Rolando Claure-Del Granado, MD, FASN

• Carlos-Rodríguez, Verónica N., Universidad Mayor de San Simon, Cochabamba, Bolivia, Plurinational State of

Verónica N. Carlos-Rodríguez, MD

• Aparicio-Yuja, Sergio O., Universidad Mayor de San Simon, Cochabamba, Bolivia, Plurinational State of

Sergio O. Aparicio-Yuja, MD

Background

Obesity and diabetes mellitus are leading causes of chronic kidney disease . Patients with obesity are more likely to develop chronic kidney disease and end-stage kidney failure. In the long-term, individuals with a body mass index (BMI) greater than 30 kg/m² have a significant higher risk of glomerular filtration rate decline. This study investigated the effects of bariatric surgery on estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (ACR) in morbidly obese patients.

Methods

Clinical variables for patients who underwent bariatric surgery were prospectively analyzed over a 12-month follow-up period between January 15, 2021, and August 14, 2023. eGFR (ml/min/1.73m²) was calculated using the serum creatinine CKD-EPI formula. Urinary ACR was measured during the follow-up. Body mass index (BMI, kg/m²), percent weight loss (%WL), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were recorded during the follow-up.

Results

Eighty-two patients were included, 48,8% (n=40) underwent bariatric surgery-laparoscopic Roux-en-Y gastric bypass (LRYGB), 39% (n=32) underwent laparoscopic sleeve gastrectomy (LSG; n = 39) and 12,2% (n=10) underwent intestinal bipartition. Baseline characteristics and follow-up parameters are presented in Table 1. The eGFR of both groups increased at the follow-up outpatient visits (months 1, 3 and 12) (p < 0.001) as shown in Table 1. The ACR decreased in the first month and twelve months after the bariatric surgery (p < 0.0001). The SBP and DBP decreased after bariatric surgery, with no significant difference between the three groups (p > 0.05).

Conclusion

Bariatric surgery is associated with improvements in postoperative renal function 1, 3 and 12 months following surgery, with significant reductions in ACR and better blood pressure control.

Table 1. Improvement in different parameters, blood pressure values, and eGFR after bariatric surgery