Kidney Week

Abstract: SA-PO943

Cardiorenal Outcomes, All-Cause Mortality, and Arterial Stiffness Parameters in Stable Kidney Transplant Recipients

Session Information

• Transplantation: Clinical - 3
  October 26, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Transplantation

• 2102 Transplantation: Clinical

Authors

• Heleniak, Zbigniew, Gdanski Uniwersytet Medyczny, Gdansk, Poland

Zbigniew Heleniak, MD, PhD

• Debska-Slizien, Alicja, Gdanski Uniwersytet Medyczny, Gdansk, Poland

Alicja Debska-Slizien, PhD, MPH

• Halleck, Fabian, Charite Universitatsmedizin Berlin, Berlin, Berlin, Germany

Fabian Halleck, DrMed

• Budde, Klemens, Charite Universitatsmedizin Berlin, Berlin, Berlin, Germany

Klemens Budde, MD

Background

The objective of the study was to evaluate the predictive value of pulse pressure (PP) and carotid-femoral pulse wave velocity (cfPWV), in relation to cardio-renal outcomes and all-cause mortality in stable renal transplant recipients (RTRs).

Methods

344 stable RTRs with a median age of 52.7 years, were enrolled. At baseline PP and cfPWV were measured during a routine visit in RTRs without cardiac symptoms and heart failure exacerbation. The follow-up was 54 months.

Results

The mean creatinine level, the value of estimated glomerular filtration rate, and transplantation vintage were 1.47mg/dl, 50.5ml/min/1.73m^2, and 73 months, respectively. The median PP and cfPWV were 55mmHg and 7.9m/s respectively. Cut-off values for all-cause mortality, CV events, and renal outcomes were: PP 60, 68, 60mmHg cfPWV 9.90, 8.0, and 10.0 m/s respectively.

During the follow-up, the likelihood of patient survival, and cardio-renall outcomes based on PP and cfPWV values (established using the Youden method) were shown in Figures 1 and 2.

Conclusion

Both PP and cfPWV have significant predictive ability for mortality and renal events outcomes in RTRs. Only the cfPWV value was predictive in terms of the incidence of CV events, significantly.