Kidney Week

Abstract: TH-PO998

Identification of Modifiable Risk Factors for Incident CKD via an Exposome-Wide Association Study

Session Information

• CKD: Epidemiology, Risk Factors, and Prevention - 1
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Kim, Yang Gyun, Kyung Hee University Hospital at Gangdong, Seoul, Korea (the Republic of)

Yang Gyun Kim, MD

• Jung, Sanghyuk, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States

Sanghyuk Jung, PhD

• Jung, Su Woong, Kyung Hee University Hospital at Gangdong, Seoul, Korea (the Republic of)

Su Woong Jung, MD, PhD

• Moon, Ju young, Kyung Hee University Hospital at Gangdong, Seoul, Korea (the Republic of)

Ju young Moon, MD, PhD

• Lee, Sangho, Kyung Hee University Hospital at Gangdong, Seoul, Korea (the Republic of)

Sangho Lee, DrMed

• Kim, Dokyoon, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States

Dokyoon Kim, PhD

Background

Chronic kidney disease (CKD) has no specific treatment, making the control of modifiable risk factors crucial in mitigating kidney disease and related complications. This study aimed to clarify the variable modifiable factors associated with incident CKD.

Methods

We analyzed 351,123 European participants from the UK Biobank who had not been diagnosed with CKD. An exposome-wide association study was conducted with 271 modifiable factors to find associations with incident CKD. Genetically high-risk patients were defined as those having a high polygenic risk score for CKD stage 3 or higher, based on a large-scale genome-wide association study from CKDGen Consortium.

Results

The mean age of subjects was 57.33±7.94 years. CKD occurred in 12,259 cases over a median follow-up period of 11.85 years. Of the 271 risk factors, 155 were significantly associated with incident CKD: 63 factors were protective, while 92 factors had detrimental effect on disease development (Figure 1). When dividing the factors into five main domains- lifestyle, environmental, psychological, socio-economic status, and physical components- 66.24%, 27.27%, 61.76%, 85.19%, and 72.41% significantly contributed to developing CKD in each domain, respectively. Higher physical activity, better pulmonary function, and more coffee intake were the strongest protective factors against the development of CKD, whereas frequent chest pain, physical restriction, and low satisfaction were the highest risk factors. This pattern was consistent across the different CKD genetic risk groups.

Conclusion

This study identified critical modifiable risk factors for incident CKD development. Even for individuals with a high genetic risk, managing these risk factors can effectively reduce the likelihood of developing CKD.

Figure 1