ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on X

Kidney Week

Abstract: SA-PO1102

Albuminuria, eGFR, and Cancer Risk: The Chronic Kidney Disease Prognosis Consortium

Session Information

Category: CKD (Non-Dialysis)

  • 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Mok, Yejin, CKD Prognosis Consortium, New York, New York, United States
  • Lees, Jennifer S., CKD Prognosis Consortium, New York, New York, United States
Background

Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results. We quantified the independent associations of albuminuria and estimated glomerular filtration rate (eGFR) with cancer risk overall and among selected site-specific cancers in the CKD Prognosis Consortium (48 cohorts).

Methods

We performed individual-participant data meta-analysis of 715,713 individuals without a history of cancer. Adjusted Cox models were used to quantify the associations of urine albumin-to-creatinine ratio (ACR) and serum creatinine-based eGFR with overall and site-specific cancer risk.

Results

94,417 incident cancer cases occurred during 17,416,991 person-years of follow-up (incidence rate of 22.2 per 1000 person-years). Higher ACR was positively associated with cancer risk [HR 1.07 (1.05-1.09 per 8-fold increase in ACR], whereas no consistent association of eGFR with cancer risk was seen [HR 1.01 (0.99 - 1.03) per 15 ml decrease in eGFR]. For the cross-categories of ACR and eGFR, higher ACR was associated with higher risk for overall cancer risk, irrespective of eGFR levels. For site-specific cancer, lower eGFR showed a significant association with urological cancer, multiple myeloma, and prostate cancer, whereas higher ACR was related to many types of cancer (i.e., head/neck, colorectal, liver, pancreas, lung, hemolymphatic, leukemia, and multiple myeloma), in addition to kidney-related cancer. Results were similar after excluding incident cases within 1 year to minimize the possibility of reverse causation.

Conclusion

CKD measures, particularly albuminuria, were independently associated with subsequent risk of cancer. Our result warrant investigation into the pathways from albuminuria to cancer.

Funding

  • NIDDK Support