Kidney Week

Abstract: SA-PO400

Small-Vessel Disease in Patients with ESKD Evidenced by Elevated Peak Width of Skeletonized Mean Diffusivity

Session Information

• Hemodialysis and Frequent Dialysis - 2
  October 26, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Dialysis

• 801 Dialysis: Hemodialysis and Frequent Dialysis

Authors

• Heo, Changmin, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)

Changmin Heo, DrMed

• Kim, Yang Wook, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)

Yang Wook Kim, MD, PhD

• Park, Bongsoo, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)

Bongsoo Park, MD

• Park, Sihyung, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)

Sihyung Park, MD

• Lee, Yoo jin, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)

Yoo jin Lee, MD

• Jeong, Eul Jo, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)

Eul Jo Jeong, MD, DrPH

• Yi, Jiyae, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)

Jiyae Yi, MD

Background

The peak width of skeletonized mean diffusivity (PSMD) is a novel marker for small vessel disease. The aim of this study was to investigate the small vessel disease in patients with end-stage renal disease (ESRD) using PSMD.

Methods

We prospectively enrolled patients with ESRD, and also included age and sex-matched healthy controls. Diffusion tensor imaging (DTI) was performed using the three tesla MRI scanner in patients with ESRD and healthy controls. We obtained the PSMD based on the DTI by several steps including preprocessing, skeletonization, application of a custom mask, and histogram analysis. We compared the PSMD between the groups, and also performed correlation analysis between PSMD and clinical factors.

Results

We enrolled the 38 patients with ESRD and 38 healthy controls. There was significant difference of the PSMD between the patients with ESRD and healthy controls. The PSMD was higher in the patients with ESRD than that in the healthy control group (2.945 vs. 2.552×10^-4 mm²/s, p<0.001, Fig 1). In addition, the PSMD was positively correlated with age (r=0.370, p=0.022). However, PSMD did not differ depending on the types of dialysis or presence of diabetes mellitus.

Conclusion

We demonstrate that patients with ESRD exhibit higher PSMD compared to healthy controls, indicating greater small vessel disease. The findings provide crucial information for clinical management and treatment strategies, highlighting the importance of addressing small vessel disease in patients with ESRD.

Figure 1. Difference in the PSMD between patients with ESRD and healthy controls