Abstract: FR-PO241
Association of Rotating Night-Shift Work with Kidney Stone Risk in the Nurses' Health Studies
Session Information
- Mineral Bone Disease: Transplant and Kidney Stones
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Bone and Mineral Metabolism
- 502 Bone and Mineral Metabolism: Clinical
Authors
- Crivelli, Joseph J., The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, United States
- Wood, Kyle, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, United States
- Schernhammer, Eva S., Brigham and Women's Hospital, Boston, Massachusetts, United States
- Curhan, Gary C., Brigham and Women's Hospital, Boston, Massachusetts, United States
Background
Night shift work is associated with adverse health outcomes including cancer and cardiovascular disease. The extent to which sleep behavior influences kidney stone risk is unknown. We examined the association of rotating night shift work (RNSW), a state of chronically disrupted circadian biology, with incident kidney stone risk in the Nurses’ Health Studies (NHS).
Methods
Female participants of NHS I and II with no history of kidney stone disease at baseline (1988-1989) were included in this analysis. Lifetime duration (in years) of RNSW (≥3 night shifts per month plus day and evening shifts) was determined at baseline in NHS I and II and updated every 2-4 years in NHS II. We used multivariable adjusted Cox models to estimate the risk of incident kidney stone disease as a function of RNSW.
Results
A total of 63,493 participants of NHS I and 91,497 participants of NHS II met study criteria. During 24 years of follow-up in NHS I and 32 years of follow-up in NHS II, there were 1,874 and 4,550 incident kidney stones. There was no statistically significant association between duration of RNSW and incident kidney stones in NHS I and II. However, in NHS II, compared to women who have not worked RNS, those with current RNSW had statistically significantly higher kidney stone risk (hazard ratio, 1.13 [95% confidence interval, 1.02-1.26]), with risk decreasing as time since stopping RNSW increased (Figure).
Conclusion
Among female registered nurses, current RNSW was associated with increased kidney stone risk, with waning risk after cessation; however, a consistent dose-response relationship between duration of RNSW and kidney stone risk was not observed.
Hazard ratios of incident kidney stone disease among participants of NHS II stratified by time since stopping rotating night shift work (RNSW). No history of RNSW is the reference group.
Funding
- NIDDK Support