Kidney Week

Abstract: SA-PO365

Elevated Serum Homocysteine Associated with Left Ventricular Remodeling in Patients with IgA Nephropathy

Session Information

• Hypertension, CVD, and the Kidneys: Clinical Research
  October 26, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Hypertension and CVD

• 1602 Hypertension and CVD: Clinical

Authors

• Yu, Hao, Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

Hao Yu, MD

• Li, Zizhen, Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

Zizhen Li

• Han, Qianqian, Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

Qianqian Han

• Wu, Huicong, Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

Huicong Wu

• Zhang, Rui, Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

Rui Zhang

• Zeng, Weicong, Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

Weicong Zeng, MD

• Li, Jiajia, Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

Jiajia Li

• Yang, Qiongqiong, Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

Qiongqiong Yang, PhD

Background

Homocysteine(Hcy) is a non-traditional independent risk factor for cardiovascular disease. Left ventricular remodeling(LVR) is a predictor of poor cardiovascular and renal outcomes in patients with chronic kidney disease(CKD). However, there is little known about LVR in IgA nephropathy(IgAN). We aimed to explore the association between serum Hcy and LVR in IgAN patients.

Methods

This retrospective study included 257 patients with IgAN who underwent echocardiography. LVR was defined as left ventricular mass index(LVMI)>115g/m² in men and>95g/m² in women or relative wall thickness(RWT)>0.42. Spearman correlation and logistic regression analysis were performed to explore the association between Hcy and LVR.

Results

In our study, 28.79% of patients had LVR, and the proportion increased with CKD progression. Patients with LVR were older and had higher serum Hcy[13.95(10.65,19.10) vs 10.90(8.80,13.70)µmol/L, P<0.001], body mass index(BMI), blood pressure(BP), serum creatinine(Scr), 24-hour urine protein, triglyceride(TG), and serum phosphorus(P), but lower haemoglobin(Hb) and serum bicarbonate compared to patients without LVR. An adjusted multivariate logistic regression model indicated that elevated serum Hcy was independently associated with increased risk of LVR(OR=1.072, 95%CI=1.001-1.149, P=0.047).

Conclusion

Serum Hcy was associated with LVR independent of traditional cardiovascular risk factors as BP, Scr and TG in IgAN patients.

Levels of serum Hcy in LVR group and non-LVR group. ***P<0.001

Levels of serum Hcy in groups according to heart structure. ***P<0.001