Abstract: SA-PO1150
Chronic Organophosphate Intoxication Developed End-Stage Kidney Failure
Session Information
- CKD: Patient-Oriented Care and Case Reports
October 26, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2302 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Hurtado Uriarte, Maite, Baxter Renal Care Services, Bogota, Bogota, Colombia
- Alvarez, Johanna, Fundacion Santa Fe de Bogota, Bogota, Bogota, Colombia
Introduction
Organophosphates, which are commonly used as pesticides, are highly toxic and can enter the body through the skin, lungs, and gastrointestinal tract. They directly affect acetylcholinesterase (AChE), leading to overstimulation of cholinergic neurons. Exposure to organophosphates has been identified as a significant non-traditional cause of chronic renal failure.
Case Description
A nineteen-year-old fumigator with no prior medical history presented with symptoms including headache, cramps, palpitations, fatigue, anorexia, and seizures over the past 20 days. Upon arrival at the emergency room, he was found to have metabolic acidosis and compromised kidney function, requiring ventilator support and immediate renal replacement therapy.
Infectious and autoimmune causes were ruled out. A renal biopsy was performed, revealing 66% global sclerosis, 15% segmental sclerosis, retracted basement membrane, cortical infarction, and changes consistent with thrombotic microangiopathy.
Discussion
Chronic kidney disease is a significant global health concern, leading to premature mortality, increased cardiovascular risk, and reduced quality of life. Pesticide exposure, particularly in agriculture, heightens the risk of kidney damage. It is crucial to remain alert about this public health issue.