Abstract: TH-PO730
Long-Term Outcomes of BK Viremia in Kidney Transplant Recipients
Session Information
- Transplantation: Clinical - 1
October 24, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 2102 Transplantation: Clinical
Authors
- Chandrashekar, Sneha, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States
- Tandukar, Srijan, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States
- Shah, Divyash V., University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States
- Bloom, Roy D., University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States
Background
BK viremia (BKV) occurs in 10-30% of kidney transplant (KT) recipients. It has not been shown to adversely impact short and intermediate term graft and patient outcomes, but long term impact is unknown.
Methods
We included KT alone recipients between 2008 and 2013 without prior history of KT and those who were alive with a functioning graft beyond 90 days of KT. We split the cohort into BK never positive, transient BKV (<140 days) and persistent BKV (>140 days). Outcomes were graft and patient survival, kidney function, de novo DSA and acute rejection over 10 years of follow up. Survival analysis was performed using Kaplan Meier (KM) analysis.
Results
Among 762 patients, there were 596, 68 and 98 patients in BK never positive, transient BKV and persistent BKV groups respectively. There was no difference in GFR at 10 years (p=0.29), acute rejection (p=0.15) and de novo class I DSA development (p=0.75). De novo class II DSA developed more often in persistent BKV group (p=0.03). On KM analysis, there was no difference in graft (p=0.6) and patient survival (p=0.86).
Conclusion
BKV does not impact long-term outcomes in KT recipients although there is a higher risk of de novo class II DSA development.
| Category | BK never positive (N=596) | Transient BK viremia (N=68) | Persistent BK viremia (N=98) | p value |
| Recipient ethnicity: Black | 26 (38.2%) | 202 (33.9%) | 51 (52%) | 0.53 |
| Recipient age | 53 (11) | 51 (13) | 52 (12) | 0.004 |
| Recipient gender: Female | 35 (51.5%) | 300 (50.3%) | 43 (43.9%) | 0.47 |
| Donor age | 37 (15) | 39 (15) | 39 (14) | 0.68 |
| Donor gender: Female | 35 (51.5%) | 300 (50.3%) | 43 (43.9%) | 0.47 |
| Peak PRA: Class I | 30 (36) | 42 (31) | 55 (35) | 0.1 |
| Peak PRA: Class II | 61 (29) | 49 (30) | 67 (29) | 0.18 |