Abstract: SA-PO666
Urinary DKK3 as a Novel Biomarker for Kidney Function Decline in Children with Alport Syndrome
Session Information
- Pediatric Nephrology - 2
October 26, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pediatric Nephrology
- 1900 Pediatric Nephrology
Authors
- Boeckhaus, Jan, Universitatsmedizin Gottingen, Gottingen, Niedersachsen, Germany
- Gross, Oliver, Universitatsmedizin Gottingen, Gottingen, Niedersachsen, Germany
Background
CKD progression in children with Alport syndrome (AS), a common genetic kidney disease, is hard to predict.
DKK3 predicts declining kidney function in adults and advanced CKD children, but its usefulness in early AS detection is unknown.
Methods
Urine samples from 50 children enrolled in the EARLY PRO-TECT Alport trial were analyzed to address this hypothesis.
Results
DKK3 levels were higher than those of the general population reported in the literature. DKK3 levels were also higher elevated in patients with later AS stages. Furthermore, children, who were not treated with RASi, had higher DKK3 levels compared to treated children. Children with above-average DKK3 levels were more likely to experience increased albuminuria compared to children with below-average DKK3 levels after 2 years of follow-up.
Conclusion
This study demonstrated that urinary DKK3, a biomarker for CKD progression, is significantly increased in children at very early stages of AS. Children with above-average DKK3 had higher risk of disease progression.
| Age (years) | 9.0±4.2 |
| Male no. (%) | 49 (98) |
| Mode of inheritance | - |
| X-linked | 44 (88) |
| Autosomal | 5 (10) |
| Unknown | 1 (2) |
| BMI (kg/m2) | 18±4 |
| Systolic/diastolic blood pressure (mmHg) | 105±13/60±9 |
| Creatinine (mg/dl) | 0.5±0.2 |
| eGFR (ml/min/1.73 m2) | 127±25 |
| Albuminuria (mg/g creatinine) | 54 (160) |
| RASi | 42 (84) |
| AS stage | - |
| 0 | 22 (44) |
| I | 19 (38) |
| II | 9 (18) |