Kidney Week

Abstract: PUB443

Acute Kidney Disease in Patients with COVID-19 and Cancer in Intensive Care: A Clinical and Retrospective Study

Session Information

• Publication Only

Category: Onconephrology

• 1700 Onconephrology

Authors

• Brito, Germana Alves, A C Camargo Cancer Center Centro Internacional de Pesquisa, Sao Paulo, São Paulo, Brazil

Germana Alves Brito, MD

• Alves, Joubert Araujo, A C Camargo Cancer Center Centro Internacional de Pesquisa, Sao Paulo, São Paulo, Brazil

Joubert Araujo Alves

• Fernandes, Alexandre Ricardo da Silva, A C Camargo Cancer Center Centro Internacional de Pesquisa, Sao Paulo, São Paulo, Brazil

Alexandre Ricardo da Silva Fernandes, RN

• Baptista, Aline Lourenco, A C Camargo Cancer Center Centro Internacional de Pesquisa, Sao Paulo, São Paulo, Brazil

Aline Lourenco Baptista, MD

• Imanishe, Marina Harume, A C Camargo Cancer Center Centro Internacional de Pesquisa, Sao Paulo, São Paulo, Brazil

Marina Harume Imanishe

• Pereira, Benedito J., A C Camargo Cancer Center Centro Internacional de Pesquisa, Sao Paulo, São Paulo, Brazil

Benedito J. Pereira, MD, PhD

Background

As cancer patients are a high-risk group for COVID-19, it is important to understand the potential complications they may experience, such as acute kidney disease (AKD). This study aimed to investigate the clinical characteristics and risk factors associated with AKD in cancer patients with COVID-19

Methods

The study was conducted retrospectively, using data from patients who were hospitalized with SARS-CoV2 infection. Demographic, clinical, and laboratory data were collected, and statistical analysis was performed using SPSS 29.0.

Results

In total, 143 patients were evaluated, of which 59.4% were male and aged 65.5±12.8 years. The majority (81.1%) had a solid tumor. During their hospital stay, 43.3% of patients developed AKD, with 25.8% requiring renal replacement therapy (RRT). Patients with AKD were more likely to have hypertension (64.5%) and cardiovascular diseases (32.3%). They also required more mechanical ventilation (MV) (71.7%), prone position (18.0%), and vasoactive drugs (VAD) (75.8%) (Table). The mortality rate was significantly higher in patients with AKD (72.6%) compared to those without AKD (39.5%). After 12 months, 44 patients were followed up, of which 84% did not have AKD and 16% developed AKD due to COVID-19 while in the ICU.

Conclusion

AKD in cancer patients with COVID-19 admitted to the ICU was more common in older patients with underlying hypertension or cardiovascular diseases. These patients required more invasive procedures such as MV, prone position, and VAD. The mortality rate was high even after discharge from the ICU.

Logistic regression of risk factors for AKD in patients with cancer and COVID-19 in the ICU