Abstract: TH-PO1138
Survival of COVID-19 Infection after Integrated Resource Planning Vaccination among Thai Patients on Hemodialysis: An Observational Cohort Study
Session Information
- COVID-19
October 24, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Coronavirus (COVID-19)
- 000 Coronavirus (COVID-19)
Authors
- Rattanasompattikul, Manoch, Golden Jubilee Medical Center, Faculty of Medicine Siriraj Hospital, Phutthamonthon District, Thailand
- Sritippayawan, Suchai, Nephrology Division, Department of Medicine, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand
- Raksasuk, Sukit, Nephrology Division, Department of Medicine, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand
- Pattharanitima, Pattharawin, Nephrology Unit, Department of Medicine, Faculty of Medicine, Thammasat University, Pathumtani, Thailand
- Srithongkul, Thatsaphan, Nephrology Division, Department of Medicine, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand
Background
In response to the pressing issue of limited vaccine supply and initial vaccine source acceptance, heterologous vaccination schedules were adopted, and integrated resource planning (IRP) and management were implemented. This study aims to estimate the change in odds of COVID-19 death following the Thai-IRP vaccination model in maintenance hemodialysis (MHD) patients.
Methods
An authorized committee thoroughly reviewed the data of patients receiving MHD admitted due to COVID-19 from January 2020 to December 2021. The sources of the databases for analysis are described in Figure 1. Conditional logistic regression was a fully adjusted model for mortality by dose and each type of vaccine.
Results
In total, 5824 MHD patients were identified with COVID-19 infection (53% male; mean age 58± 14 years). The mortality rate was 7% (N =409), with the underlying disease of diabetes and hypertension (17%), only diabetes (21%), and only hypertension (42%). Covariates associated with mortality in subgroups of the population at risk were significant with age ≥ 60 years, highest BMI and lowest nPNA, crude odds ratio (ORs) [95% CI] were 1.90 [1.54, 2.34], 1.65 [1.29, 2.13] and 1.77 [1.22, 2.56], respectively. The ORs focusing on the mortality outcome of various vaccinations showed that two doses of each vaccine type decreased mortality. The single dose of inactive SARSCoV-2 virus vaccines and ChAdOx1 nCoV-19 vaccine demonstrated increased ORs in the fully adjusted model (2.15 [0.82, 5.67] and 2.22 [1.17, 4.20]).
Conclusion
Our study underscores that age (≥ 60 years old), highest BMI, and lowest nPNA are associated with death in severe acute respiratory syndrome coronavirus two infections. Notably, the Thai-IRP model vaccination demonstrates a clear benefit from the first vaccination dose compared with no vaccine group in each type of vaccine, except the ChAdOx1 nCoV-19 vaccine, which showed an adverse outcome from the first vaccination dose.
Figure 1
Funding
- Government Support – Non-U.S.