Kidney Week

Abstract: TH-PO970

Association of Cardiovascular-Kidney-Metabolic Syndrome with Cognitive Decline and Dementia: The ARIC Study Insights

Session Information

• Physical Activity and Lifestyle in Kidney Diseases
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Health Maintenance, Nutrition, and Metabolism

• 1500 Health Maintenance, Nutrition, and Metabolism

Authors

• Xie, Peichen, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

Peichen Xie, PhD

• Wang, Yiqin, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

Yiqin Wang

• Chen, Wei, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

Wei Chen, MD, PhD

Background

Cardiovascular-kidney-metabolic(CKM) syndrome is a prevalent health concern, while its impact on cognitive function has not been extensively studied.

Methods

We conducted a prospective analysis with Atherosclerosis Risk in Communities (ARIC) study data. CKM risk was assessed with the PREVENT^TM Calculator and cognitive function was evaluated using z score from different cognitive function tests at Visit 2 and Visit 4. Dementia cases were identified through a combination of assessments and hospital records, with analyses adjusted for demographics and vascular risks during Visit 5.

Results

Our study included 10,960 participants with a mean age of 56.9±5.7 years. A robust inverse relationship was observed between cognitive function and CKM risk, with the inflection point at 6.381% CKM risk for the global z score. The risk of dementia increased with higher CKM risk (HR 1.14, 95% CI 1.13-1.16). Notably, male participants exhibited a comparatively reduced risk of dementia (HR 0.72, 95% CI 0.63-0.82). A subsequent sensitivity analysis, utilizing baseline data from Visit 4 (n=4644), confirmed these results.

Conclusion

Our findings indicate a significant link between CKM risk and cognitive decline, suggesting the importance of CKM syndrome management in preventing cognitive impairment and dementia.

RCS of CKM risk and cognitive scores

Cumulative dementia rates across different risk strata of CKM