Kidney Week

Abstract: SA-PO1069

Impact of Smoking Status on Hemoglobin Levels and Progression of CKD in Patients in a Metabolic Disorder Cohort

Session Information

• CKD: Epidemiology, Risk Factors, and Prevention - 3
  October 26, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Choi, Hoon Young, Yonsei University College of Medicine, Seodaemun-gu, Korea (the Republic of)

Hoon Young Choi, MD, PhD

• Kim, Hyo Jeong, Yonsei University College of Medicine, Seodaemun-gu, Korea (the Republic of)

Hyo Jeong Kim, MD

• Park, Hyeong cheon, Yonsei University College of Medicine, Seodaemun-gu, Korea (the Republic of)

Hyeong cheon Park, MD, PhD

Background

Smoking has been known as one of the leading causes of preventable deaths worldwide. Smoking has also known as the risk developing chronic kidney disease (CKD). The hemoglobin level for incident CKD in metabolic patient groups can vary depending on various factors such as age, gender, the specific metabolic disorder, the stage of CKD, and smoking status.
This study investigated the relationship between hemoglobin levels and the progression of CKD depends on smoking status.

Methods

In the data from the medical records database in Gangnam Severance Hospital from 2006 through 2020, a longitudinal analysis included participants with CKD. Progression of CKD was defined by a reduction in the GFR ≥30% of baseline. Logistic regression analyses were used to determine the association between hemoglobin level and progression of CKD according to smoking status by adjusting for the influence of confounders.

Results

The study included 4,176 patients, of whom 986 had smoking status. Mean hemoglobin levels were 13.7 ± 1.9 g/dl (non-smoker) and 14.2 ± 1.9g/dL (smoker) according to smoking status. Among non-smoker, highest and second highest quartiles of hemoglobin levels was decreased with the risk progression of CKD [OR 0.664, OR 0.405, P<0.001] after adjusting for age, sex, hypertension status, diabetes status, and alcohol status. However, the risk progression of CKD was significantly decreased only in the second highest quartile of hemoglobin levels among smoker [OR 0.669, P=0.017].

Conclusion

Our study provides evidence that smoking is associated with elevated hemoglobin levels, and hemoglobin levels may have varying implications for CKD progression depending on smoking status.