Kidney Week

Abstract: FR-PO1083

The Burden of Ventricular Premature Complexes Is an Independent Risk Factor of the Development of Kidney Failure in Patients with CKD

Session Information

• CKD: Epidemiology, Risk Factors, and Prevention - 2
  October 25, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Yu, Chih-Hen, National Cheng Kung University College of Medicine, Tainan, Taiwan

Chih-Hen Yu, MD, MS

• Chen, Chao-Yu, National Cheng Kung University College of Medicine, Tainan, Taiwan

Chao-Yu Chen

• Lee, Chien-Shien, National Cheng Kung University College of Medicine, Tainan, Taiwan

Chien-Shien Lee, MD

• Huang, Ting-Chun, National Cheng Kung University College of Medicine, Tainan, Taiwan

Ting-Chun Huang

• Lee, Po-Tseng, National Cheng Kung University College of Medicine, Tainan, Taiwan

Po-Tseng Lee, MD, MS

• Huang, Mu-Shiang, National Cheng Kung University College of Medicine, Tainan, Taiwan

Mu-Shiang Huang, MD

• Liu, Ping-Yen, National Cheng Kung University College of Medicine, Tainan, Taiwan

Ping-Yen Liu, MD, PhD

• Wu, An-Bang, National Cheng Kung University College of Medicine, Tainan, Taiwan

An-Bang Wu, MD

• Tseng, Chin Chung, National Cheng Kung University College of Medicine, Tainan, Taiwan

Chin Chung Tseng, MD

• Sung, Junne-Ming, National Cheng Kung University College of Medicine, Tainan, Taiwan

Junne-Ming Sung, DrMed, PhD

Background

Ventricular premature complexes (VPCs) are strongly linked to heart failure, and a higher VPCs burden independently increases the risk of cardiovascular mortality; however, whether the VPCs lead to renal impairment beyond cardiovascular events remains unknown. The primary objective of the study is to assess whether a high VPCs burden serves as an independent risk factor for the development of kidney failure in CKD patients.

Methods

We conducted a single-center, perspective cohort to clarify the role of VPC burden in composite renal outcome. We follow up the patients with CKD 3b to 5, who's indicated of Holter exam. The composite renal outcome was defined as sustained eGFR decline of at least 40%, sustained GFR<15mL/min/1.73 m², maintenance dialysis, or death from kidney failure.

Results

A total of 527 patients was enrolled. The mean follow-up duration was 571 days (Q1:202, Q3:1093). Events shorter than 180 days were excluded. The hazard ratio (HR) for Log VPCs was 1.159 (95%CI, 1.030-1.305, p=0.014), adjusted for age (HR 0.986 95%CI, 0.973-0.999, p=0.041), diabetes (HR 1.428, 95%CI 1.046-1.950, p=0.025), and CKD stages (CKD stage 3: ref, stage 4: HR 2.743 95%CI 1.97-3.945, p<0.001, stage 5: HR 5.404 95%CI 3.621-8.063, p<0.001). In categories of different VPC burdens, compared to individuals with a VPC burden<100/day, HR of VPC 100-10,000 beats/day and VPC>10,000 beats/day regarding the composite outcome were 1.251(95%CI, 0.868-1.677, p=0.353), and 2.42(95%CI, 1.165-5.020, p =0.018), respectively.

Conclusion

High burden of VPCs, defined by log VPC, or with cutoff of 100 beats/day and 10,000 beats/day, are independent predictors of composite renal outcome in CKD population.

Kaplan-Meier Analyses for Composite Renal Outcome of VPC Burdens in All Patient and Different CKD Stages