Abstract: PUB457
Comparison of Spot Creatinine Estimation by StatSensor Creatinine Meter and Serum Creatinine Estimation by Conventional Enzymatic Method
Session Information
Category: Pathology and Lab Medicine
- 1800 Pathology and Lab Medicine
Authors
- Chandrasekar, Manoj, JSS Medical College, Mysore, Karnataka, India
- Shetty, Manjunath Sanjeeva, JSS Medical College, Mysore, Karnataka, India
- Hathur, Basavanagowdappa, JSS Medical College, Mysore, Karnataka, India
- Vishwanath, Prashant, JSS Medical College, Mysore, Karnataka, India
- Prashant, Akila, JSS Medical College, Mysore, Karnataka, India
- Kulkarni, Praveen, JSS Medical College, Mysore, Karnataka, India
- K K, Kiran, JSS Medical College, Mysore, Karnataka, India
- Chandra, Naman, JSS Medical College, Mysore, Karnataka, India
- Devaraju, Abhijith, JSS Medical College, Mysore, Karnataka, India
- Begos, Dennis, Nova Biomedical, Waltham, Massachusetts, United States
- Oyelakin-Ogunbileje, John O., Indiana University School of Medicine, Indianapolis, Indiana, United States
- Murthy, Vishakantha, JSS Reasearch Foundation, Gaithersburg, Maryland, United States
Background
The objective was to compare and validate creatinine measured by Nova StatSensor Creatinine meter against S.Creatinine measured by conventional enzymatic assay
Methods
Patients with renal dysfunction and age/sex matched healthy volunteers underwent Spot.creatinine measurement by Nova StatSensor Creatinine meter using capillary blood (finger prick) and Serum creatinine measurement by conventional enzymatic assay
Results
A total of 618 (320 patients and 298 healthy volunteers) were included in the study. The baseline characteristics were similar
Mean (±SD) Spot.Creatinine & S.Creatinine in the overall population was 1.9 (±1.9) & 1.8 (±1.8); 2.9 (± 2.2) & 2.8 (± 2.2) in patients; 0.86 (± 0.2) & 0.81 (± 0.2) in healthy volunteers
A Pearson coefficient depicted a positive linear correlation between Spot.Creatinine and S.Creatinine, r (df)= 1, p < 0.001.The sensitivity and specificity of Spot.Creatinine was 91.2% and 96% respectively; PPV and NPV of 94.5% and 93.6% and an accuracy of 94.1%
Conclusion
Spot.Creatinine measurement using StatSensor Creatinine meter with capillary blood is simple, rapid, reliable and provides a good estimate of creatinine
A positive, linear and strong relationship between Spot. Creatinine and S. Creatinine in patient population (r=0.89)
A positive, linear relationship of moderate strength between Spot. Creatinine and S.Creatinine in healthy population (r=0.66)
Funding
- Commercial Support – Nova Biomedical Corporation, Waltham, MA, USA