Kidney Week

Abstract: SA-PO1110

Prognostic Implications of Relative Eosinophil Counts in Nephrosclerosis

Session Information

• CKD: Epidemiology, Risk Factors, and Prevention - 3
  October 26, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Mae, Haruki, The Jikei University School of Medicine, Minato-ku, Japan

Haruki Mae, MD

• Kanzaki, Go, The Jikei University School of Medicine, Minato-ku, Japan

Go Kanzaki, MD, PhD

• Shimoyama, Kotaro, The Jikei University School of Medicine, Minato-ku, Japan

Kotaro Shimoyama, MD

• Kuno, Hideaki, The Jikei University School of Medicine, Minato-ku, Japan

Hideaki Kuno

• Hatanaka, Saeko, The Jikei University School of Medicine, Minato-ku, Japan

Saeko Hatanaka, MD

• Marumoto, Hirokazu, The Jikei University School of Medicine, Minato-ku, Japan

Hirokazu Marumoto, MD

• Sasaki, Takaya, The Jikei University School of Medicine, Minato-ku, Japan

Takaya Sasaki, MD

• Haruhara, Kotaro, The Jikei University School of Medicine, Minato-ku, Japan

Kotaro Haruhara, MD, PhD

• Tsuboi, Nobuo, The Jikei University School of Medicine, Minato-ku, Japan

Nobuo Tsuboi, MD, PhD, FASN

• Yokoo, Takashi, The Jikei University School of Medicine, Minato-ku, Japan

Takashi Yokoo, MD, PhD

Group or Team Name

• The Jikei University School of Medicine.

Background

The interplay between atherosclerosis and chronic inflammation has gained considerable recognition, with elevated eosinophil counts identified as a risk factor for cardiovascular diseases. Nonetheless, the effect of eosinophils on the kidney prognosis of patients with nephrosclerosis remains unclear.

Methods

This retrospective observational study was conducted in a single hospital. Patients diagnosed with nephrosclerosis via kidney biopsy between January 2010 and December 2023 were included in the study. Clinical data were extracted from hospital records at the time of biopsy to evaluate the association between blood relative eosinophil count (REC; percentage of eosinophil in WBC) and renal outcomes. Logarithmic transformation was performed for continuous variables to make data conform more closely to the normal distribution. The primary endpoint was dialysis initiation during follow-up. Patients were categorized into three groups based on their REC levels (REC grade 1, lower group [0.7-2.6%]; 2, middle group [2.7-4.0%]; and 3, higher group [4.2-20.5%]), and a log-rank test was performed. Cox regression analysis was conducted and adjusted for REC, age, sex, BMI, and mean arterial pressure.

Results

The cohort comprised 76 patients (median age 54.9 years, 81.6% male, with a median follow-up duration of 68.7 months [interquartile range 21.8-106.8]). Fifteen patients (19.7%) underwent dialysis. Kaplan-Meier curves with the log-rank test for time to events showed no significant difference (Log-rank p = 0.07; Figure 1). However, Cox regression analysis demonstrated that REC, as a continuous variable, was significantly associated with the initiation of dialysis (hazard ratio 1.41, 95% confidence interval 1.21-13.9).

Conclusion

Eosinophil counts may serve as a significant prognostic marker for kidney outcomes in patients with nephrosclerosis.

Figure 1