Kidney Week

Abstract: SA-PO678

Body Mass Index Trajectories among Adolescents and Young Adults with CKD

Session Information

• Pediatric Nephrology - 2
  October 26, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Pediatric Nephrology

• 1900 Pediatric Nephrology

Authors

• Parraga, Pierina P., The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, United States

Pierina P. Parraga, MD

• Easterly, Caleb W., The University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, United States

Caleb W. Easterly

• Filler, Guido, London Health Sciences Centre, London, Ontario, Canada

Guido Filler, MD, PhD

• Gilleskie, Donna B., The University of North Carolina at Chapel Hill College of Arts and Sciences, Chapel Hill, North Carolina, United States

Donna B. Gilleskie, PhD

• Ferris, Maria E., The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, United States

Maria E. Ferris, MD, PhD, MPH

Background

Nearly 1 in 5 US children and adolescents have obesity, a risk factor for cardiovascular disease. We examine longitudinal body mass index (BMI) patterns among adolescents and young adults (AYA) with chronic kidney disease (CKD) during the age of transition to adulthood.

Methods

We conducted an historical cohort study of AYA with CKD stages 1-5 aged 13-25 at a southeastern health system in the USA. Electronic medical record (EMR) appointment and laboratory data from Jan 2005-May 2015 were extracted, and CKD patients with ≥4 height and weight measurements were included (N=7,978 observations from 255 patients). Age- and sex-specific BMI Z-scores and percentiles were calculated using the 2000 CDC growth chart (normal weight: BMI >5^th and <85^th percentile; overweight: BMI ≥85^th and <95^th percentile; obese: BMI >95^th percentile). We modeled BMI Z-score as a linear function of age allowing for different intercepts and slopes for adolescents (aged 13-19) and young adults (aged 20-25), adjusting for sex, race/ethnicity, birth year, and CKD etiology (glomerular, non-glomerular, other primary diagnosis). Logistic regression estimated the proportion of patients with overweight or obesity by age.

Results

At baseline, patients’ mean age was 14.9 years, 53% were male; 35% had glomerular conditions, 32% non-glomerular conditions, and 33% had other primary diagnoses. BMI Z-scores decreased with age among adolescents (-0.066 standard deviations [SD] per year of age; P = 0.022) and increased with age for young adults (0.170 SD per year of age; P < 0.001). The proportion of adolescents with overweight or obesity did not change with age (P = 0.643), but the proportion of young adults with overweight or obesity increased by 0.037 with each year of age (P < 0.001), reaching 0.62 by age 25.

Conclusion

Trends in BMI increase as adolescents with CKD move into young adulthood.

Adjusted for age, race/ethnicity, birth year, and CKD etiology. 95% confidence intervals are shaded.