Kidney Week

Abstract: FR-PO1119

Association between Alcohol Consumption and the Risk of Incident CKD in Community-Dwelling Older Adults

Session Information

• CKD: Epidemiology, Risk Factors, and Prevention - 2
  October 25, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Oh, Ju hwan, Presbyterian Medical Center, Jeonju, Jeollabuk-do , Korea (the Republic of)

Ju hwan Oh, MD

• Sun, In O, Presbyterian Medical Center, Jeonju, Jeollabuk-do , Korea (the Republic of)

In O Sun, MD, PhD

• Bae, Eunjin, Gyeongsang National University Hospital, Jinju, Korea (the Republic of)

Eunjin Bae, PhD

• Kwon, Soon hyo, Soonchunhyang University Hospital, Yongsan-gu, Seoul, Korea (the Republic of)

Soon hyo Kwon, MD

• Yu, Byung chul, Soonchunhyang University Hospital Bucheon, Bucheon, Gyeonggi-do, Korea (the Republic of)

Byung chul Yu, MD, PhD

• Yang, Jae Won, Wonju Severance Christian Hospital, Wonju, Gangwon-do, Korea (the Republic of)

Jae Won Yang, MD, PhD

• Hwang, Won Min, Konyang University Hospital, Daejeon, Korea (the Republic of)

Won Min Hwang, MD, PhD

• Hong, Yu Ah, The Catholic University of Korea Daejeon St Mary's Hospital, Daejeon, Korea (the Republic of)

Yu Ah Hong, MD, PhD

Background

The relationship between alcohol consumption and kidney function decline is not established in older adults. This study aimed to investigate the effects of alcohol consumption on the risk of incident CKD in community-dwelling older adults.

Methods

Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 between 2009 and 2010 were recruited and followed through 2018 from a Korean national population-based cohort. Alcohol consumption was categorised into non, mild, moderate, and heavy drinking groups based on self-administered questionnaires. New-onset CKD was defined as an eGFR <60 mL/min/1.73 m2 .

Results

Of the total 122,319 subjects, the non, mild, moderate, and heavy drinking groups were 99,091 (81.0%), 14,842 (12.1%), 4,257 (3.5%), and 4,139 (3.4%). During follow-up, 19,796 (20.0%), 4,636 (31.2%), 1,696 (39.8%), and 1,695 (41.0%) developed CKD in the non, mild, moderate, and heavy drinking groups. Univariate Cox regression analyses showed a increased risk of incident CKD in older adults in all drinking groups compared to non-drinkers (all P < 0.001). However, hazard ratios for developing CKD were 0.90 (95% CI 0.87–0.94, P < 0.001) for mild, 0.89 (95% CI 0.84–0.95, P < 0.001) for moderate, and 0.93 (95% CI 0.88–0.99, P = 0.027) for heavy drinkers after fully adjusting for confounding variables. This inverse relationship between alcohol consumption and CKD risk was observed in males in all drinking groups, whereas in females it was found in mild drinkers.

Conclusion

In the subgroup analysis, the beneficial effect of alcohol consumption on incident CKD was prominent among moderate drinkers aged 65–75 years, male mild drinkers aged ≥ 75 years, and female mild drinkers aged < 85 years. This study shows that alcohol consumption is inversely associated with the risk of incident CKD in older adults. Further studies are required to elucidate the effects of alcohol on kidney damage in older adults.