Abstract: SA-PO1064
Association of Marital Status with CKD Progression and Mortality: Analyses from the CRIC Study
Session Information
- CKD: Epidemiology, Risk Factors, and Prevention - 3
October 26, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Herrera-Enriquez, Karela B., Brigham and Women's Hospital Department of Medicine, Boston, Massachusetts, United States
- McCausland, Finnian R., Brigham and Women's Hospital Department of Medicine, Boston, Massachusetts, United States
Background
Being married is associated with lower mortality among patients with several disease types. Whether marital status is associated with future risk of kidney failure among patients with chronic kidney disease (CKD) is not clear.
Methods
Using data from the Chronic Renal Insufficiency Cohort (CRIC; n=5,625), we explored the association of marital status (never, former, current) with a composite kidney outcome (≥50% decline in estimated glomerular filtration rate [eGFR], eGFR <15, transplant, or dialysis) and mortality. Unadjusted and adjusted Cox models were fit, adjusting for age, race, body mass index, education, income, systolic blood pressure, diabetes, myocardial infarction or revascularization, peripheral vascular disease, heart failure, current smoking status, eGFR, 24-hour urine protein, hemoglobin, serum albumin, and medications (beta-blocker, calcium blocker, ACEi or ARB, aspirin, statin, or diuretic). We also explored if associations differed according to sex.
Results
Mean age was 60 ±11 years; 44% were female; 43% self-reported as Black; baseline eGFR was 49 ±16 ml/min/1.73m2. At baseline 2,994 (53%) reported being married, 1,830 (33%) formerly married, and 801 (14%) never married. Over a median follow-up of 5.1 years, there were 1,501 (27%) kidney composite events and 1,890 (34%) deaths. In adjusted analyses, compared with never married, those currently married had a lower risk of the kidney composite (HR 0.80; 95%CI 0.66, 0.96) and all-cause mortality (HR 0.76; 95%CI 0.63, 0.91). The association of marital status with the kidney composite and death appeared to differ according to sex (P-interaction=0.16 and 0.04, respectively), such that lower risks were observed for males, versus females (Table 1).
Conclusion
Marital status is independently associated with a lower risk for adverse kidney outcomes and death among patients with CKD. These associations appeared to be most potent among male patients.