Abstract: PUB491
Use of the Monocyte-to-Lymphocyte Ratio to Predict Delayed Graft Function in Patients after Kidney Transplantation
Session Information
Category: Transplantation
- 2102 Transplantation: Clinical
Author
- Jariyayothin, Irin, Police General Hospital, Bangkok, Thailand
Background
Delayed graft function (DGF) is a significant complication following kidney transplantation, affecting graft survival. The monocyte-to-lymphocyte ratio (MLR) is being explored as a potential predictor of DGF, reflecting inflammatory and immune responses. Evaluating MLR's utility in predicting DGF could improve patient management post-transplantation.
Methods
Medical records of patients undergoing kidney transplantation at Police General Hospital from January 1989 to December 2023 were reviewed. DGF was defined as a temporary impairment of kidney function immediately after transplantation, requiring dialysis within the first week post-transplant. Clinical data and laboratory were collected. The optimal cut-off value for MLR was determined using receiver operating characteristic (ROC) curve analysis. Univariate and multivariate logistic regression models were performed to investigate the risk factors associated with DGF.
Results
A retrospective cohort study was conducted on 162 kidney transplant patients, of which 58 had DGF, while 104 did not. Clinical outcomes focused on DGF, with MLR investigated as a potential biomarker. In the receiver-operating characteristic (ROC) curve analysis, MLR, with an optimal cut-off value of 0.255 (AUC of 0.686; 95% CI 0.603, 0.769; P < 0.001), predicted the DGF with a sensitivity of 81.0% and specificity of 55.8%. The multivariate logistic regression analysis confirmed that MLR was an independent factor of DGF (MLR) >0.255 (Adj. OR 3.74 [95% CI 1.55, 9.02], P=0.003).
Conclusion
This study suggested that high MLR may associated with DGF. The MLR is an inexpensive and straightforward indicator to reflect systemic inflammation status to help clinicians improve kidney transplant care.