Abstract: FR-PO244
Combined Occurrence of Cardiovascular and Bone Events in Individuals with Kidney Stone Disease
Session Information
- Mineral Bone Disease: Transplant and Kidney Stones
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Bone and Mineral Metabolism
- 502 Bone and Mineral Metabolism: Clinical
Authors
- Ferraro, Pietro Manuel, Universita degli Studi di Verona, Verona, Veneto, Italy
- Taylor, Eric N., Maine Medical Partners, Portland, Maine, United States
- Curhan, Gary C., Brigham and Women's Hospital, Boston, Massachusetts, United States
Background
Kidney stone disease (KSD) has been linked to increased risk of adverse cardiovascular (CV) and bone events. This has led to the hypothesis that a shared pathogenic pathway may underlie these events. However, it is unclear whether adverse CV and bone events commonly occur in the same individual. We examined the patterns of occurrence of CV and bone events in individuals with a history of KSD and analyzed their characteristics.
Methods
We analyzed data from three large prospective cohorts, the Health Professionals Follow-up Study (HPFS, men) and the Nurses’ Health Study (NHS, women) I and II. Individuals with a self-reported diagnosis of KSD during follow-up and no previous CV or bone events at the time of KSD diagnosis were included in the study and followed until the combination of a CV event (fatal or non-fatal myocardial infarction, need for coronary revascularization) and a bone event (fracture, osteoporosis); individuals who developed cancer or were lost to follow-up were censored. Characteristics of stone formers who experienced only one event (CV or bone), both events, or none were compared with the appropriate statistical tests.
Results
Our study included data from 15,041 individuals with KSD. In HPFS, 28.7% of the participants experienced at least one event: 17.4% a CV event, 8.4% a bone event and 2.8% both events. In NHS I, 46.9% of the participants experienced at least one event: 7.4% a CV event, 33.2% a bone event and 6.3% both events. In NHS II, 27.8% of the participants experienced at least one event: 2.2% a CV event, 24.5% a bone event and 1.1% both events. Baseline characteristics according to the type of event experienced are reported in Table 1: across cohorts, age, BMI, use of thiazides, use of calcium and vitamin D supplements, prevalence of hypertension and diabetes tended to differ between groups.
Conclusion
Cardiovascular and bone events are common in KSD; however, their simultaneous occurrence in the same individual is uncommon, suggesting that risk factors might not be shared between cardiovascular and bone events.
Funding
- NIDDK Support