Kidney Week

Abstract: SA-PO1096

Association of Calcium-to-Magnesium Intake Ratio with Albuminuria in Community-Dwelling Japanese Adults

Session Information

• CKD: Epidemiology, Risk Factors, and Prevention - 3
  October 26, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Kabasawa, Keiko, Niigata University, Niigata, Japan

Keiko Kabasawa, MD, PhD, MPH

• Hosojima, Michihiro, Niigata University, Niigata, Japan

Michihiro Hosojima, MD, PhD

• Nakamura, Kazutoshi, Niigata University, Niigata, Japan

Kazutoshi Nakamura

• Takachi, Ribeka, Nara Women's University, Nara, Japan

Ribeka Takachi, PhD, RD

• Tanaka, Junta, Niigata University, Niigata, Japan

Junta Tanaka, MD, PhD

• Narita, Ichiei, Niigata University, Niigata, Japan

Ichiei Narita, MD, PhD

• Ito, Yumi, Niigata University, Niigata, Japan

Yumi Ito, MD, PhD

Background

Calcium and magnesium both work together and counteract each other. In the kidneys, filtered calcium and magnesium are reabsorbed in consecutive segments from the proximal tubule to the connecting duct, where both are used in albumin handling. Previous studies have suggested that the calcium-to-magnesium intake ratio is associated with chronic health conditions such as cardiovascular disease; however, its relationship with albuminuria is not known.

Methods

This study analyzed data from 6,849 Japanese community-dwelling adults age ≥40 years (51.3% women). We cross-sectionally assessed the calcium-to-magnesium intake ratio and each nutrient using a validated food frequency questionnaire and spot urine albumin-to-creatinine ratio (ACR). Linear regression analyses were performed for the relationships of natural log-transformed intake ratio, calcium intake, and magnesium intake with natural log-transformed ACR, with adjustments for potential confounders.

Results

Median values of the calcium-to-magnesium intake ratio and eGFR were 1.65 and 73.5 mL/min/1.73 m², respectively. In the multivariable linear regression analysis, the calcium-to-magnesium intake ratio was inversely associated with log-transformed ACR [β(95%CI), −0.085 (−0.15, −0.021)]. When calcium and magnesium intake were analyzed individually, each nutrient was inversely associated with log-transformed ACR but the relationship with magnesium intake was not independent of calcium intake (Table).

Conclusion

The calcium-to-magnesium intake ratio was inversely associated with albuminuria. The balance of calcium and magnesium intake may be a potential modifiable factor for preventing albuminuria, and calcium intake may be a main contributor to this association.

Multivariable linear regression analysis for the relationship of natural logarithms of calcium-to-magnesium intake ratio, calcium intake, and magnesium intake with the natural logarithm of ACR

Funding

• Government Support – Non-U.S.