Abstract: SA-PO1127
Patient-Reported Outcomes and Associations with Clinical Events in a Cohort of People with Nondialysis-Dependent CKD
Session Information
- CKD: Patient-Oriented Care and Case Reports
October 26, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2302 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Patel, Dipal M., The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
- Han, Dingfen, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
- Parikh, Chirag R., The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
- Shin, Jung-Im, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States
- Riekert, Kristin, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
- Crews, Deidra C., The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
Background
People with CKD face substantial disease burden and impairments to quality of life (QOL). The distribution and severity of these patient-reported outcomes (PROs), and whether they are associated with clinical outcomes, is underexplored for people with non-dialysis dependent CKD.
Methods
We quantified general health, QOL, and physical and mental health symptoms, as reported by people with CKD G3-5 who completed an electronic PRO assessment tool prior to Johns Hopkins (JH) nephrology clinic follow-up visits. We performed multivariable regression analyses to investigate the association of PROs with dialysis initiation and 1-year hospitalization.
Results
We collected 2180 PRO assessment tool responses from 1091 individuals with CKD G3-5 (Figure). QOL, general health, and some symptoms were worse for people with advanced stages of CKD compared to earlier stages. Among the full cohort, 99 individuals (9%) were hospitalized within 1 year (231 total number of hospitalizations), and 177 (16%) started dialysis. After adjustment for age, sex, comorbidities, and individual measures of socioeconomic status, low self-reported general health was associated with higher risks for hospitalization and dialysis initiation, with every one-point increase in general health scores being associated with a 12% reduction in incidence of hospitalization and a 17% reduction in the risk of dialysis initiation.
Conclusion
People with non-dialysis-dependent CKD experience several symptoms and impairments to QOL and self-perceived general health. Our findings highlight the utility of PRO assessment in identifying people at high risk for adverse outcomes including hospitalization and dialysis initiation.
Select PRO assessment tool scores and associations with clinical outcomes. Lower scores represent lower QOL and general health, and more prevalent physical and mental health symptoms.
Funding
- Other NIH Support