Kidney Week

Abstract: TH-PO1036

Periodontal Disease, Its Treatment, and the Risk of Kidney Failure among US Veterans

Session Information

• CKD: Epidemiology, Risk Factors, and Prevention - 1
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Patel, Nilang G., VA Richmond Medical Center, Richmond, Virginia, United States

Nilang G. Patel, MD, MS, FASN

• Silvey, Scott, Virginia Commonwealth University Department of Internal Medicine, Richmond, Virginia, United States

Scott Silvey, MS

• Bajaj, Jasmohan S., VA Richmond Medical Center, Richmond, Virginia, United States

Jasmohan S. Bajaj, MD, MBBS, MSc

Background

Association of periodontal disease(PD) on incidence and progression of CKD is unknown.

Methods

Retrospective study conducted on veterans eligible for continuous and comprehensive dental care from 2009-2014. Veterans with a baseline eGFR > 60 ml/min/1.73m² were followed from the date of their initial comprehensive dental exam until the end of 2019. Patients divided into three groups: Periodontal disease (PD), Periodontal disease with treatment (PT) and no periodontal disease (no-PD). The composite outcome included: incident CKD, a 40% drop in eGFR, transplant/dialysis, or death.

Results

86,376 veterans (age 57.17±12.59, 91.4% male) were included in the final cohort. 12,172(14.1%) had untreated PD, 20,283 (23.5%) had PT and 53,921 (62.4%) had No-PD. The median follow-up was 7.39 yrs. Table 1 shows baseline characteristics and outcomes.

Upon analyzing the primary composite outcome, PD patients had significantly increased risk over time(HR,1.18 [1.12-1.24], p<0.001), as did PT patients (HR:1.05 [1.01-1.09], p=0.02) (Fig. 1). After adjusting all covariates, PD associated with higher rates of the composite outcome (aHR:1.08 [1.01-1.15], p=0.025), while the PT was no longer statistically significant.

Conclusion

Untreated periodontal disease is linked to an increased Incident CKD and CKD progression. Treated PD associated with better outcomes.

Funding

• Veterans Affairs Support