Abstract: SA-PO567
In Vitro Per- and Polyfluoroalkyl Substances (PFAS) Adsorption Assessment through Mesoporous Styrene-Divinylbenzene Sorbent Cartridge
Session Information
- Bioengineering
October 26, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Bioengineering
- 400 Bioengineering
Authors
- Lorenzin, Anna, Department of Nephrology, Dialysis and Transplantation, St. Bortolo Hospital, Vicenza, Italy
- Perin, Natascha, Department of Nephrology, Dialysis and Transplantation, St. Bortolo Hospital, Vicenza, Italy
- de Cal, Massimo, Department of Nephrology, Dialysis and Transplantation, St. Bortolo Hospital, Vicenza, Italy
- Brendolan, Alessandra, International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy
- Zanella, Monica, Department of Nephrology, Dialysis and Transplantation, St. Bortolo Hospital, Vicenza, Italy
- Ronco, Claudio, International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy
Background
Per- and polyfluoroalkyl substances (PFAS) are chemical substances used in a wide range of fields as construction materials, biocides, flame retardants etc. Due to their high stability in the environment and resistance to biodegradation, all PFAS are persistent, and many are highly mobile in global waters. High blood levels of PFAS have been associated with adverse health effects including increased risk of kidney or testicular cancer. Classic extracorporeal therapies have demonstrated limited efficiency and new approaches based on adsorption should be explored. The aim of this study was to assess the potential adsorption capacity of HA380 cartridge towards PFAS from patients with high blood levels.
Methods
We developed an in-vitro model of hemoadsorption using GALILEO testing platform. We recirculated a highly polluted batch of water (4 liters) through a HA380 cartridge (Jafron medical, Zuhai, China) for 120 minutes at a flow rate of 150mL/min (Figure a). We collected samples after 5,30,60, and 120 minutes from the initiation of circulation and analyzed 39 different PFAS compounds. Removal Ratio (RR) was calculated to assess PFAS adsorption.
Results
PFAS compounds with concentrations significantly above normal showed a RR close to 90% already within the first 60 minutes of circulation leading to almost complete elimination of all pollutants at the end of the circulation (Figure b). RR is remarkably high already at the outset of the adsorption process demonstrating a high capacity of removal of HA380 cartridge. This is likely dependent on the interaction of the different solutes with the molecular structure of the sorbent.
Conclusion
The in-vitro model of hemoadsorption suggests the possible application in-vivo of this technique to reduce/normalize the concentrations of PFAS in patients exposed to water or environmental pollution. Hemoadsorption may therefore be considered as a new possible approach in patients with high blood levels of PFAS.