Abstract: FR-PO1147
Assessment of Nutritional Status in Nondialysis-Dependent Patients with CKD Using Handgrip Strength
Session Information
- CKD: Kidney Function and Extrarenal Complications
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2302 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Kim, Minsang, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
- Im, Dha Woon, Eulji University Uijeongbu Eulji Medical Center, Uijeongbu, Gyeonggi-do, Korea (the Republic of)
- Kang, Eunjeong, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
- Oh, Kook-Hwan, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
Group or Team Name
- KNOW-CKD (The KoreaN Cohort Study on the Outcome of Chronic Kidney Disease Patients).
Background
Although handgrip strength (HGS) has been suggested as an indirect assessment of nutritional status in chronic kidney disease (CKD) patients, additional evidences regarding the diagnostic usefulness of HGS for malnutrition in non-dialysis-dependent CKD (NDD-CKD) are warranted.
Methods
A total of 467 patients enrolled in the Phase II KoreaN Cohort Study for Outcome in Patients With CKD who underwent nutritional assessment were included in this study. The exposure was the maximum value of HGS, which was measured twice in each hand. The outcome was a malnutrition status defined as a malnutrition-inflammation score (MIS) of 6 or higher. In this cross-sectional study, the risk of malnutrition was calculated using logistic regression analysis adjusted for age, sex, history of diabetes mellitus (DM), stage of CKD, and income and education status. Predictability of HGS for malnutrition was assessed by area under the curve (AUC) using receiver operating characteristic curve analysis.
Results
Patients with lower HGS, defined as HGS values below sex-specific median values, were older and had a higher proportion of DM. A higher HGS was significantly associated with a lower risk of malnutrition after adjustment (per 1 standard deviation increase, adjusted odds ratio, 0.51 [0.26–0.98]). I]). In the subgroup analyses stratified by age, sex, DM, and CKD stage, these clinical factors did not show significant interaction between HGS and the risk of malnutrition. The tendency of a negative association between HGS and the risk of malnutrition was consistently observed in all subgroups. Furthermore, HGS exhibited fair significance for the prediction of malnutrition in men and women (Figure 1).
Conclusion
HGS is a useful diagnostic indicator of malnutrition in NDD-CKD patients.
Funding
- Government Support – Non-U.S.