Kidney Week

Abstract: FR-PO910

Incident Diabetes in Glomerular Diseases

Session Information

• Glomerular Diseases: Potpourri
  October 25, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Glomerular Diseases

• 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics

Authors

• Haddad, Samuel, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Samuel Haddad

• Andrews, Calvin, Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States

Calvin Andrews, MS

• Helmuth, Margaret, University of Michigan, Ann Arbor, Michigan, United States

Margaret Helmuth, MA

• Smith, Abigail R., Northwestern University, Evanston, Illinois, United States

Abigail R. Smith, PhD

• Nast, Cynthia C., Cedars-Sinai Medical Center, Los Angeles, California, United States

Cynthia C. Nast, MD, FASN

• Mottl, Amy K., The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Amy K. Mottl, MD, MPH, FASN

Background

Glomerular diseases (GDs) can result in significant kidney morbidity. Comorbid diabetes (DM) can occur following GD onset and may exacerbate the rate of decline in eGFR. We examined risk factors for incident DM, and the association of incident DM with major adverse kidney events (MAKE).

Methods

Adults with MCD, FSGS, MN, or IgAN enrolled in the prospective CureGN observational cohort study were included. Multivariable Cox regression models of time from biopsy to incident diabetes and MAKE (40% decline in eGFR or ESKD) were fitted. The base model associated age at biopsy, sex, racial/ethnic minority, family history of DM, and BMI with incident DM risk. Additional models sequentially tested GD diagnosis (IgAN, FSGS, MCD, MN), smoking, baseline eGFR, and time-dependent steroid or CNI use. Associations between time-dependent diabetes incidence and MAKE were adjusted for base model covariates.

Results

Of 1,729 adults enrolled in CureGN, 142 developed incident DM (Table); median (IQR) time from biopsy to DM was 23 (5-58) months. Older age, higher BMI, and smoking history were associated with higher risk of incident DM; no associations between steroid and CNI use and risk of incident DM in GD were detected (Figure). No association between incident DM after GD diagnosis was detected for MAKE (HR=0.99; 95% CI: 0.66-1.50).

Conclusion

Long-term risks of incident DM in GD remain to be determined.

Funding

• NIDDK Support