Abstract: FR-PO327
Analysis of the Kidney-Brain Axis via the Fractional Amplitude of Low-Frequency Fluctuation in Patients with Diabetic Nephropathy
Session Information
- Diabetic Kidney Disease: Clinical Modeling, Diagnosis, Education, and More
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Diabetic Kidney Disease
- 702 Diabetic Kidney Disease: Clinical
Author
- Lv, Jinlei, Renal Division, The First Affilliated Hospital of NanChang University, NanChang, China
Background
Central neuropathies caused by diabetic nephropathy (DN) may share similar characteristics. The fractional amplitude of low-frequency fluctuation (fALFF) technique was applied to detect resting brain function alterations in patients with diabetic nephropathy, and their relationships with Brain clinical manifestations and the kidneys and are discussed.This study aimed to analyze the changes in brain function of patients with DN based on the kidney–brain axis.
Methods
We recruited patients with DN and healthy controls (n=23 per group). All participants underwent brain resting-state functional magnetic resonance imaging examination, and the fractional amplitude of low-frequency fluctuation (fALFF) values were calculated. The sensitivity, specificity, and Youden index were used to assess the authenticity of the diagnosis by constructing receiver operating characteristic curves. We analyzed the correlation between mean fALFF values and DN data using Pearson’s correlation.
Results
Compared with control subjects, patients with DN had lower fALFF values in the right cingulum anterior segment (RCA) and left cingulum middle segment（LCM）, and increased fALFF values in the right cingulum middle segment（RCM）. Furthermore, the mean fALFF values in the RCA correlated with the estimated glomerular filtration rate in DN patients.
Conclusion
There were significant changes in brain function in DN patients compared to the control group. Changes in the central nervous system in patients with DN were mainly due to the dual negative effects of kidney function and diabetes mellitus. We found significant differences in fALFF values in the default mode network and visual cortex-related areas, which may be highly valuable for understanding the kidney–brain axis mechanisms of DN, as well as the associations between diabetic microvascular complications.
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Funding
- Government Support – Non-U.S.