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Kidney Week

Abstract: FR-PO1081

Association of Renal Artery Calcium Scoring with Decline in eGFR

Session Information

Category: CKD (Non-Dialysis)

  • 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Aslam, Nabeel, Mayo Clinic, Jacksonville, Florida, United States
  • Mason, Danielle, Lincoln memorial DeBusk College of Osteopathic Medicine, Harrogate, Tennessee, United States
  • Khambati, Ibrahim, Mayo Clinic, Jacksonville, Florida, United States
  • Hikida, Hiroshi Dean, Mayo Clinic, Jacksonville, Florida, United States
  • Trautman, Christopher L., Mayo Clinic, Jacksonville, Florida, United States
  • Jarmi, Tambi, Mayo Clinic, Jacksonville, Florida, United States
Background

Coronary artery calcium scoring is associated with adverse cardiovascular events and a lower estimated glomerular filtration rate (eGFR). However, limited data exist on the association of renal artery calcium (RAC) scoring with the rate of decline of eGFR.

Methods

We conducted a single center, retrospective study of adult patients followed in a nephrology clinic with available CT imaging of the abdomen. Data collected included demographics, comorbidities, medications, and eGFR at 3-month intervals for 24 months post-CT scan. Aorta and RAC scoring was calculated using a semiautomated software package designed for quantifying coronary artery calcium by the Agaston method.

Results

A total of 274 patients were included in the analysis: median age 67 years, 65% males, and 90% white. Comorbid conditions included diabetes mellitus 31%, hypertension 82%, hyperlipidemia 68%, and pre-existing chronic kidney disease (CKD) 69%. The cohort was divided into groups based on RAC score: RAC = 0; 1-100; >100. RAC >100 was significantly associated with the decline in eGFR from baseline to 24 months as compared to the RAC 0 group (p=0.03). There was no significant association between RAC 1-100 and RAC 0 with the decline in eGFR from baseline to 24 months (p=0.75). There was no association of aorta calcium scoring with a change in eGFR from baseline to 24 months (p=0.23 ).

Conclusion

In our cohort, RAC score >100 is associated with a decline in eGFR over the 24 months of follow-up. RAC score may provide prognostic information for eGFR decline in patients with risk factors for developing CKD or pre-existing CKD. Further studies are needed to evaluate the utility of RAC scoring in identifying patients at higher risk of eGFR decline.

Funding

  • Clinical Revenue Support