Abstract: FR-PO392
Association of Prevalent Kidney Stone Disease with All-Cause and Cardiovascular Disease Mortality among US Adults
Session Information
- Hypertension, CVD, and the Kidneys: Epidemiology
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1602 Hypertension and CVD: Clinical
Authors
- Shringi, Sandipan, Rhode Island Hospital, Providence, Rhode Island, United States
- Raker, Christina A., Lifespan Biostatistics, Epidemiology, Research Design, and Informatics Core, Providence, Rhode Island, United States
- Tang, Jie, Rhode Island Hospital, Providence, Rhode Island, United States
Background
Kidney stone (KS) disease is associated with multiple cardiovascular disease (CVD) risk factors. We have reported survival among stone formers from US adults from 1988-1994. We now report all-cause and CVD mortality in prevalent KS disease defined as self-report of any previous episode of KS using updated dataset of US adults from 2007-2018.
Methods
We examined the relationship between KS disease and risk of death among a nationally representative sample of US adults (age ≥20 years) using the National Health and Nutrition Examination Survey (NHANES) 2007-2018 and its linked mortality file. Cox proportional hazard regression analyses were used to estimate the risks of all-cause and CVD death.
Results
27,959 participants were eligible for the final analysis including 2,689 prevalent KS formers. Stone formers tended to be non-Hispanic, white males, had a higher BMI, and more likely to have hypertension, diabetes, and CVD. There was a total of 2,445 all-cause deaths and 601 CVD deaths. Unadjusted analysis showed that stone formers had a higher risk of death from all-causes (HR 1.63, 95% CI: 1.38-1.93, p<0.001) but not CVD (HR 1.28, 95% CI: 0.94-1.75, p=0.12). However, after multivariate adjustment, stone formers no longer had an increased risk of death from all-causes compared to non-stone formers (HR 0.93, 95% CI: 0.80-1.09, p=0.38). Furthermore, risk of death from CVD after multivariate adjustment was lower in stone formers (HR 0.65, 95% CI: 0.47-0.91, p=0.01). [Table]
In comparison, in NHANES III (1988-1994), there was a total of 6,069 all-cause deaths and 1,839 CVD deaths. Unadjusted analysis showed that stone formers had a higher all-cause and CVD mortality, however, there was no independent association of KS disease with all-cause or CVD mortality after multivariate adjustment.
Conclusion
Unlike NHANES III, NHANES 2007-2018 shows that prevalent KS disease is independently associated with lower CVD mortality but not all-cause mortality. Further studies are needed to confirm this finding.
Hazard ratios for all-cause and CVD deaths in stone formers