Abstract: PUB135
Effect of Dialysis Dose on Nutritional Status of Patients on Hemodialysis
Session Information
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Padua, Kiara Marie H., Makati Medical Center, Makati City, Philippines
- Cayco, Antonio Villegas, Makati Medical Center, Makati City, Philippines
- Bisquera, Mary Rose, Makati Medical Center, Makati City, Philippines
Background
Malnutrition is common among dialysis patients and impacts morbidity and mortality. Underdialysis causes malnutrition, but it is not known if high dialysis doses (Kt/V ≥1.65) lead to greater intradialytic nutrient loss, inflammation and protein catabolism. This study challenged the hypothesis that a higher dialysis dose increases the risk of malnutrition.
Methods
This is a pilot, single-center, prospective cohort. Aidamea online Kt/V was averaged for 6 months and compared with the change in dry weight, body mass index (BMI), mid-upper arm circumference (MUAC) for anthropometrics, modified SGA score, albumin, blood urea nitrogen (BUN), creatinine, and total lymphocyte count (TLC) as laboratory parameters.
Results
There is an inverse correlation between high Kt/V and anthropometric parameters and BUN. As Kt/V increases, it is more likely to have a BMI <18.5 (OR 2.6), SGA B (OR 1.19) and TLC <1500 (OR 1.07), and less likely to have albumin <3.4 (OR 0.25), though associations were not statistically significant.
Conclusion
The discordant results may be due to the high sieving coefficient for albumin, adequate protein repletion, and use of a single-use dialyzer in the center. A longer observation period may be needed. Thus, it is essential to individualize the approach when interpreting each parameter.
Patient Flow Diagram
Correlation of HD doses to Nutritional Parameters