Kidney Week

Abstract: PUB551

Vascular Aging (VA) Analyzed by Dermal Autofluorescence (DA) on the Risk of Initiating Renal Replacement Therapy (RRT) and Mortality in Patients with Nondialysis-Dependent CKD Stages 1 to 5

Session Information

• Publication Only

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Cigarran, Secundino, Hospital Ribera Polusa, Lugo, Lugo, Spain

Secundino Cigarran, MD, MBChB, PhD

• Sanjurjo Amado, Ana Maria, Hospital Publico da Mariña, Burela, Lugo, Spain

Ana Maria Sanjurjo Amado, RN

• Santidrián Novo, Amaia, Hospital Ribera Polusa, Lugo, Lugo, Spain

Amaia Santidrián Novo, RN

• Vázquez Rodríguez, Raquel, Hospital Ribera Polusa, Lugo, Lugo, Spain

Raquel Vázquez Rodríguez

• Rios, Jose, Hospital Clinic de Barcelona, Barcelona, Catalunya, Spain

Jose Rios, MSc, PhD

• Perez Fontan, Miguel, Complexo Hospitalario Universitario A Coruna, A Coruna, Galicia, Spain

Miguel Perez Fontan

• Barril, Guillermina, Fundacion Investigaciones Biomedicas, Madrid, Madrid, Spain

Guillermina Barril, MD, PhD

Background

CKD is age-related disease that displays multiple features of accelerated ageing and considered as an early aging process measured through VA. Aim is to examine VA as risk for RRT and mortality in CKD stage 1-5ND.

Methods

Oservational, prospective,longitudinal study, 1064 pts followed 14 years, 59.8% male, 40.2% female.Χ age 72.07±14.13 yr. Markers of nutrition,inflammation,and cardiovascular risk evaluated.Kidney Failure Risk Equation (KFRE) for CKD progression. Mortality was considered for all causes. Frailty by Clinical Frailty Scale. VA from advanced glycation end products (AGEs) by AGEs Reader (Diagnoptics Technologies BV, Groningen, the Netherlands).Koetsier formula .(Vascular Age = AFD - 0.83/0.024).Tertil low (<73 yrs,594 pts),medium (73-107 yrs,509 pts),and high (>107 yrs, 501 pts).Lowest tertile was reference.

Results

VA 20.05±31.85 years over chronological.Significance with Charlson comorbidity,Frailty,higher 5-year mortality, KFRE, FRAX for osteoporotic fracture, and risk of hip fracture. VA > 15.6 yrs was independent risk for RRT or death as competitive event (Log Rank; p < 0.001), mean time to RRT 15.08 yrs (50% 15.33 years). Conversely, VA<15.6 yrs mean time to RRT 21.30 years (50% 28 years) Figure 1. Mortality low tertile 9.6% i16.3% medium and 30.6% high (Log Rank; p < 0.001, HR 2.70; 95% CI 1.669-4.399; p < 0.001) Figure 2.

Conclusion

VA>15.6 years start RRT 13 years earlier and 50% higher mortality than <15.6 yrs.VA is a predictor of RRT and mortality. DA is a useful tool for risk RRT & mortality in CKD.

Funding

• Private Foundation Support