Kidney Week

Abstract: FR-PO1135

Assessing Kidney Function Markers and Myocardial Perfusion Imaging with Thallium-201 in Patients with CKD

Session Information

• CKD: Kidney Function and Extrarenal Complications
  October 25, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2302 CKD (Non-Dialysis): Clinical, Outcomes, and Trials

Authors

• Su, Wei-Yu, Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

Wei-Yu Su, MD

• Lin, Yi-Ting, Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

Yi-Ting Lin, MD, PhD

• Lin, Ming-Yen, Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

Ming-Yen Lin, PhD

• Kuo, Mei-Chuan, Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

Mei-Chuan Kuo, MD

• Chiu, Yi-Wen, Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

Yi-Wen Chiu, MD

• Tsai, Yi-chun, Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

Yi-chun Tsai, MD

• Chang, Jer-Ming, Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

Jer-Ming Chang, MD, PhD

• Hwang, Shang-Jyh, Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

Shang-Jyh Hwang, MD

• Wu, Ping-Hsun, Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

Ping-Hsun Wu, MD, MS

Background

Chronic kidney disease (CKD) is a substantial public health challenge worldwide, associated with elevated morbidity and mortality rates. Myocardial perfusion imaging (MPI), a non-invasive diagnostic modality, can detect early-stage cardiovascular disease in patient with CKD. This study aimed to investigate the association between renal function and semi-quantitative parameters of Thallium-201 MPI in CKD patients.

Methods

This retrospective study included 1443 CKD patients who underwent Thallium-201 MPI between August 2008 and December 2021. The risk classification proposed by the Kidney Disease Improving Global Outcomes (KDIGO) guidelines is based on estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (UACR). Semi-quantitative parameters were analyzed using AutoQUANT Version 6.5 software.

Results

Multivariable analysis showed that both lower eGFR and higher UACR stage were significantly associated with worse myocardial perfusion parameters, including higher summed motion scores (SMS), summed motion (SM), summed thickening scores (STS), summed thickening (ST), end-diastolic volume (EDV) and end-systolic volume (ESV), and lower left ventricular ejection fraction (LVEF). Higher CKD stage was significantly associated with increased odds of higher summed difference score (SDS), ST, and SM. Higher UACR stage was significantly associated with increased odds of higher ST. Furthermore, KDIGO category classified as very high risk was significantly associated with higher summed stress score, summed stress percentage, summed rest score, summed rest percentage, SDS, summed difference percentage (SD), stress extent of perfusion defects, stress total perfusion deficit (sTPD), resting extent of perfusion defects, resting total perfusion deficit, SMS, SM, STS, ST, EDV, ESV, lower LVEF, and increased odds of higher lung-to-heart ratio, sTPD, SDS, ST, and SM.

Conclusion

The results suggest that worse kidney function is associated with poorer myocardial perfusion and left ventricular function in participants with CKD, which can inform clinical decision-making, risk stratification, and targeted management strategies for CKD patients, ultimately aiming to improve their cardiovascular outcomes and overall prognosis.