Abstract: FR-PO505
The Role of SFRP2 in Vascular Remodeling of Arteriovenous Fistula (AVF) Maturation
Session Information
- Dialysis Vascular Access
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 803 Dialysis: Vascular Access
Author
- Liu, Chung-te, Division of Nephrology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, n/a, Taiwan
Background
The glycoprotein SFRP2 is known to activate Wnt/β-catenin signaling and myofibroblast transition in myocardial fibrosis. Previous studies have indicated that myofibroblast proliferation is present in the vascular thickening of arteriovenous fistula (AVF). Thus, it’s hypothesized that SFRP2 may promote AVF maturation.
Methods
In the prospective observational study, native veins (NV) harvested during AVF creation surgeries were examined to determine the correlation between preoperative SFRP2 expression and AVF maturation. In addition, SFRP2 expression was compared between mature and immature AVF. In mouse experiment, SFRP2 will be administered intravenously to find its effect on vascular wall remodeling.
Results
We had obtained 69 specimens of NV during the surgery of AVF creation, which contains 22 mature AVF and 47 nonmature AVF at 2 months. The results showed a trend of higher SFRP2 expression in NV that matured. (Figure 1A-C). Additionally, we collected 7 mature AVF from thrombectomy and 2 nonmature AVF in revision surgery. A trend of higher SFRP2 expression in mature AVF was found. (Figure 1D-F). The above results have not achieved statistical significance. The animal experiment showed that SFRP2 treatment induced vascular wall thickening, increased expression of αSMA and nuclear colocalization of β-catenin similar to that in AVF. (Figure 2).
Conclusion
Our preliminary data showed that SFRP2 may induce vascular wall remodeling associated with AVF maturation in human. Nonetheless, its exact role needs confirmation in further investigation.