Kidney Week

Abstract: SA-PO1094

Potential Reduction of Proteinuria by Oral Care Using Chlorhexidine Gluconate

Session Information

• CKD: Epidemiology, Risk Factors, and Prevention - 3
  October 26, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Misaki, Taro, Seirei Hamamatsu Byoin, Hamamatsu, Shizuoka, Japan

Taro Misaki, MD, PhD

• Naka, Shuhei, Okayama Daigaku Daigakuin Ishiyakugaku Sogo Kenkyuka, Okayama, Okayama, Japan

Shuhei Naka, PhD

• Ito, Seigo, Koku Jieitai Iruma Kichi, Sayama, Saitama, Japan

Seigo Ito, MD

• Nagasawa, Yasuyuki, Hyogo Ika Daigaku, Nishinomiya, Hyogo, Japan

Yasuyuki Nagasawa, MD, PhD

• Nomura, Ryota, Hiroshima Daigaku, Higashihiroshima, Hiroshima, Japan

Ryota Nomura, MD

• Matsumoto-Nakano, Michiyo, Okayama Daigaku Daigakuin Ishiyakugaku Sogo Kenkyuka, Okayama, Okayama, Japan

Michiyo Matsumoto-Nakano

• Nakano, Kazuhiko, Osaka Daigaku, Suita, Osaka, Japan

Kazuhiko Nakano, PhD

Background

Chlorhexidine mouthwash is widely used as an antimicrobial agent to reduce bacterial load in the oral cavity. However, its effects on systemic conditions in patients with chronic kidney disease (CKD) are still unknown. In the present study, we examined the relationship between the number of Streptococcus mutans in the oral cavity and proteinuria.

Methods

The patients with CKD gargled with chlorhexidine mouthwash three times daily for one year. We investigated the relationship between changes in the number of S. mutans and proteinuria.

Results

The S. mutans ≥1000 group at 0 month was significantly associated with higher number of S. mutans, urinary protein (g/gCr) and higher % urinary protein 2 + or higher in over time. Mean of the number of S. mutans in the oral cavity in whole patients decreased significantly over time. Proteinuria also decreased significantly with a delay. Relationship between the degree of decrease in the number of S. mutans after 12 months and proteinuria less than 0.3 g/gCr after 12 months remained significantly different in logistic regression analysis adjusted for age, sex, and proteinuria(g/gCr) at baseline (0 month). Additionally, the rate of proteinuria less than 0.3g/gCr at 12 months was significantly higher in the group that achieved S. mutans <1000 at 12 months.

Conclusion

These results suggest that there was a relation between the number of S. mutans in the oral cavity and proteinuria in patients with CKD and oral care with chlorhexidine mouthwash may reduce the proteinuria.